RF therapeutic cancer apparatus and method

ABSTRACT

An apparatus and method for treating cancer and other illnesses in humans and animals are described. The treatment involves the low-power, pulsed application of radio frequency tuned with precision of at least one half part per million. Alternative embodiments are described for apparatus that generates the required RF signals and applies such signals therapeutically. Laboratory data is reported, showing the successful use of the disclosed apparatus and methods to suppress and eliminate cancerous tumors in mice.

FIELD OF INVENTION

[0001] This invention generally relates to apparatus and methods for treating cancer and other illness in humans and animals, and more particularly to a therapeutic apparatus and method based upon the administration of precisely regulated, low power, pulsed electromagnetic radiation (EMR).

BACKGROUND OF THE INVENTION

[0002] There is a considerable body of early literature regarding treatment of various illnesses with radio frequencies (RF) in the 43 MHz range. In U.S. Pat. No. 2,545,087, F. J. Hart disclosed an apparatus for treating a subject with a sequence of radio frequencies in the 43 MHz. range, applied in a step-wise fashion. These frequencies were each modulated sinusoidally at 60 Hz., and further pulsed by a second slow sinusoidal oscillator operating at 90 cycles per minute (1.5 Hz.). The RF frequencies employed by Hart were specified to three decimal places.

[0003] The instruments available to Hart and the other researchers of his day were based on tube amplifiers, which resulted in oscillators with considerable drift that could not be precisely tuned. Hart's means for applying the RF energy to a subject most often consisted of a metal plate acting as an antenna. As a result of such oscillator drift and imprecision, and the inefficiency of the available output devices, Hart and his contemporaries were not able to conduct scientific tests with precisely controlled frequencies, or to discover optimal treatment modalities.

[0004] Modern electronic technologies make it relatively simple to construct more precise and stable instruments than Hart had at his disposal. As a consequence, it has become possible to study systematically the potential therapeutic value of EMR. The present inventors have undertaken such studies over the course of many years, and as a result have perfected apparatus and methods which have proved effective in treating cancerous tumors in laboratory mice. The inventors believe that the same methods can be effectively adapted for human treatment.

[0005] The present inventors have constructed apparatus designed to overcome the limitations of Hart's approach. They have further sought to establish the utility of their invention through a program of animal testing, and have in turn used the results of such testing to refine the apparatus and the methods for effectively using such apparatus. The resulting apparatus and methods, and the experimental results of applying such apparatus and methods to treat cancerous tumors in mice, will be described below.

SUMMARY OF THE INVENTION

[0006] It is generally the object of the present invention to utilize electromagnetic radiation to provide effective treatments for cancer and other illnesses.

[0007] It is a further object of this invention to achieve reliable and reproducible therapeutic results from EMR treatment methods by achieving precise control over the treatment frequency.

[0008] It is also an object of the present invention to provide an efficient means of transmitting EMR from the generating means to the subject.

[0009] It is another object of the present invention to provide an EMR treatment that may be applied at very low power levels that can cause no harm.

[0010] These and other objects are achieved in accordance with the present invention through the use of an apparatus involving an oscillator that outputs, at a power of less than one mw, an RF frequency in the 43 MHz range, regulated and stabilized to the fifth or sixth decimal place, which is in turn modulated with a 60 Hz. 50% duty cycle square wave, which is in turn gated, again on a 50% duty cycle, at a rate of 1.167 Hz. (70 pulses per minute).

[0011] The RF frequency is chosen for a particular subject based on the believed effectiveness of the frequency in treating the illness in question, as summarized herein.

[0012] The modulated RF signal output by the apparatus of the present invention is applied to a flat loop of wire approximately 60 cm. long, grounded at one end and wound in five flat, concentric spiral-rectangular turns spaced about 3.175 mm. apart, the loop (herein referred to as a “treatment loop”) being mounted on an insulating layer adhesively bonded to a metal plate.

[0013] In using this apparatus, the metal plate is placed, loop down, on the subject's body near the area to be treated. RF power is applied to the loop at one precise treatment RF frequency for at least one hour at a time. During treatment, the treatment loop is shielded from direct light and moving air currents.

[0014] There are alternative embodiments of the invention that differ somewhat in their circuit and construction details. The first, referred to as the “Battery SCPO,” is a battery-powered “Single Crystal Pulsed Oscillator” in a metal housing with an internal quartz crystal, and an integral, externally mounted treatment loop. Each Battery SCPO is limited to a single frequency. A variation is shown (the “Mouse SCPO”) in which an SCPO is powered by an external DC power module rather than batteries. An alternate embodiment, referred to as the “Generator Embodiment”, derives its treatment signal from the modulated output of a Hewlett-Packard Model 8662A frequency generator, and supplies the signal to the treatment loop over a short coaxial cable. The frequency and power of the Generator Embodiment is easily adjusted with controls on the front panel of the 8662A frequency generator. Another alternative embodiment, also based on the HP 8662A Frequency Generator, modulates the RF signal entirely externally to the HP 8662A, and employs a specific type of coaxial cable to carry the signal from the modulator to the treatment loop. These alternative embodiments differ somewhat in their circuitry and construction details, as will be more fully described below.

[0015] In any of the alternative embodiments, treatment is non-restrictive and utilizes a low power believed to be completely safe for humans.

[0016] Other features and advantages of the present invention will become apparent from the following more detailed description, taken in conjunction with the accompanying drawings, which illustrate, by way of example, the principles of the invention.

BRIEF DESCRIPTION OF THE DRAWINGS

[0017]FIGS. 1A and 1B show top and bottom external views of the Battery SCPO.

[0018]FIG. 2 is a block diagram of the major functional units of the Battery SCPO.

[0019]FIG. 3 is a schematic diagram of the Battery SCPO.

[0020]FIG. 4A shows the modulation waveform of the Battery SCPO. FIGS. 4B through 4F show spectrum analyses of the output of the Battery SCPO.

[0021]FIG. 5 is an external view of the components of the Generator Embodiment.

[0022]FIG. 6 is a schematic diagram of the modulator circuit for the Generator Embodiment.

[0023]FIGS. 7A and 7B show, respectively, the modulation waveform and a portion of the output waveform of the Generator Embodiment.

[0024]FIGS. 8A and 8B show front and back views of the treatment loop used in connection with the Generator Embodiment.

[0025] FIGS. 9A1-9J4 show the treatment housings and treatment loops used for treating mice in the experiments described herein.

[0026]FIGS. 10 through 29 show, for each treated and control mouse involved in the inventors' experimental studies, A, the locations of the tumors (if any) that developed, B, plots (on a logarithmic scale) of the respective volumes of the various tumors as a function of time, and C, plots of the mouse's weight and hematocrit measurements as a function of time.

[0027]FIG. 30A and B shows bar graphs of the life spans of the treated and control mice, respectively.

[0028]FIG. 31A and B shows bar graphs of the life spans of the treated and control mice, respectively, after tumors were detected.

[0029]FIG. 32A and B shows bar graphs of the number of tumors in the treated and control mice, respectively.

[0030]FIG. 33A and B shows bar graphs of the outcome with respect to the tumors found in the treated and control mice, respectively.

[0031]FIG. 34A and B shows bar graphs of the weight changes observed in the treated and control mice, respectively.

[0032]FIG. 35A and B shows bar graphs of the maximum size of tumors observed in the treated and control mice, respectively.

[0033]FIG. 36 is a schematic diagram for an external modulator that attaches to the radio frequency output of an HP 8662A Frequency Generator and FIG. 36A is a top view of the exterior of the device.

[0034]FIG. 37 shows, for a mouse treated with a Generator Embodiment pulsed externally by the modulator shown in FIG. 36, A, the location of the tumor that developed, B, plots (on a logarithmic scale) of tumor volume as a function of time, and C, plots of the mouse's weight and hematocrit measurements as a function of time.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 1. DESIGN CONSIDERATIONS

[0035] According to experiments conducted by the present inventors, treatment with EMR is most effective under the following conditions:

[0036] a) The treatment frequency is selected with a precision extending to the fifth or sixth decimal point, or at least one half part per million.

[0037] b) The frequency is extremely stable over the course of the treatment.

[0038] c) The precise frequency chosen is held at that frequency and applied without variation for at least one hour.

[0039] d) RF power applied to the subject is held to less than one milliwatt (mW).

[0040] e) The EMR is applied through a coiled loop of wire, which, for treatments in the 43 MHz. Range, is approximately 60 cm. long.

[0041] The frequencies listed in Table 1 are believed to be effective for treating the indicated maladies: TABLE 1 Treatment Frequencies Frequency Malady 43,322,480 Sarcoma (generalized) 43,322,492 Sarcoma (intestines) 43,322,485 Sarcoma (breast) 43,346,000 Tuberculosis (general) 43,346,090 Tuberculosis (intestines) 43,346,000 Tuberculosis (breast) 43,346,050 Common cold 43,353,800 Carcinoma (general) 43,353,800 Carcinoma (intestines) 43,353,850 Carcinoma (breast) 43,353,800 Malignancy 43,296,000 Strep 43,351,830 Treats several diseases 43,351,850 Treats several diseases 43,351,855 Treats several diseases 43,351,870 Treats several diseases 43,352,000 Pneumonia 43,245,000 Staph

[0042] The foregoing list includes all of the frequencies studied by the present inventors and found to be effective. The inventors believe that different frequencies, even close to the above-stated frequencies are not effective. They have found that the effectiveness of the treatment depends critically on the precise frequency chosen, to the precision indicated herein. They have also found that steady treatment frequencies are more effective than swept or varied frequencies.

[0043] This invention is not intended to be limited to the frequencies stated in the above table. The inventors believe that there may be other frequencies in the 43 MHz. range that the present inventors have not as yet studied, that may also be effective. Similarly, the present inventors believe that there may be effective treatment frequencies in completely different ranges, for example, at much higher frequencies. The most important factor, in the view of the present inventors, is a precisely chosen frequency steadily applied for at least an hour at a time.

2. CONSTRUCTION OF ALTERNATIVE TREATMENT DEVICES

[0044] For twenty years we have been working to obtain the correct frequencies with which to treat the mice and also the best possible instrument (method) with which to deliver the treatment to the mouse. Some of our experiments included using two plates (a hot and ground) rather than the treatment loop. All things considered, we feel the embodiments employing treatment loop electrodes have performed the best in our experiments on the mice.

[0045] Detailed descriptions of the alternate embodiments of the invention are set forth here to demonstrate that the principles taught in this invention are readily reducible to practice. It should be understood that these embodiments represent but a few of the possible configurations of the present invention, and that, utilizing the principles of the present invention as disclosed herein, analogous apparatus and methods may be readily devised for controlled therapeutic application of RF energy.

[0046] A. Battery SCPO

[0047] Top and bottom external views of the battery-operated embodiment of the treatment device are shown in FIGS. 1A and 1B. The device 100 is built in a small, self-contained rectangular metal package measuring about 7.37 cm. long, 5.46 cm. wide, and 1.78 cm. in thickness.

[0048] Housing 110 is preferably metal. It provides mechanical protection for the apparatus and serves as a electromagnetic shield. Housing 110 is soldered shut. In battery holder 114 (Caltronics BH-124) accessible from outside the package (and which may be recessed or attached to the exterior of housing 110), the housing accommodates four standard 1.5 volt “AA” alkaline batteries 115 of approximately 1.5 volts each, which provide the electrical power for the unit.

[0049] The underside of the device, shown in FIG. 1B, accommodates a surface mounted coil of wire 120 referred to as the “treatment loop.” One end of treatment loop 120 enters the bottom housing surface through a wire feed hole 140 in the bottom of housing 110. The other end of treatment loop is grounded at solder point 150 to the outside of housing 110. The treatment loop itself consists of five concentric, spiraled, rectangular turns of 20 AWG solid copper wire embedded in a 2 mm. (0.080 inch) thick sheet of high impact styrene 111 adhesively fastened to the bottom surface of housing 110. (Alternatively, the treatment loop may be constructed on a printed circuit board.) The windings are spaced 3.175 mm. apart and the overall dimensions of the loop are 2.858×5.258 cm.

[0050] The treatment loop 120 has a broad radiating pattern off the coil. It is not a “focused” radiation but a spreading radiation. More signal is available from the front then off the back of treatment loop 120 (the back is shielded by a ground plane). Tests were run using a loop without the back shield but the results were not as good as with a back shield. The signal is strongest in the center since that is where the “hot” lead connects to treatment loop 120.

[0051] The circuitry that drives treatment loop 120 is contained on a printed circuit board 190 (shown in the cutaway 180 in FIG. 1B) within housing 110. The schematic for this circuit is shown in FIG. 3. The circuit comprises two timer circuits 210 and 240, which provide approximately a 60 Hz. approximately 50% duty cycle square wave, and an approximately 70 pulse per minute (1.167 Hz.) approximate 50% duty cycle square wave, respectively. These two square waves are combined in AND gate 260 in order to produce an approximately 60 Hz. square wave pulsed at approximately 1.167 Hz., each of the 60 Hz. Square wave and the 1.167 Hz. pulse having an approximate 50% duty cycle. The waveform output by AND gate 260 is shown in FIG. 4A.

[0052] The output of AND gate 260 is then directed through filter 270, and then to quartz crystal X1 280. Although many frequencies could be chosen from, the Battery SCPOs built to date have used a crystal cut for a third harmonic frequency of 43.351830±20 Hz., 43.351850±20 Hz., 43.351855±20 Hz. and 43.351870±20 Hz. (corresponding to base frequencies in the 14.450 MHz range). These frequencies have been found most effective for treating a broad range of maladies. The output of crystal 280 is directed to treatment loop 120.

[0053] Viewed in further detail, the schematic diagram in FIG. 3 shows the power for the circuit derived from the four cell battery 301. This power supply feeds positive rail 302 and ground rail 303.

[0054] The approximately 60 Hz. timing circuit 210 is based on a low power TLC 555 timer U2 311, set up as an astable multivibrator by connecting pins 2 (Trigger) and 6 (Threshold) together. Pin 1 is connected to ground 303. Pins 4 and 8 are connected to the positive supply rail 302. Pin 5 is connected to the midpoint of a voltage divider comprised of 1K resistor R9 317 (this, and all other fixed resistors referred to herein being 5%, ¼ Watt, unless otherwise specified) from the positive supply and 2.2 K resistor R8 325 to ground 302. Pin 6 is in addition connected to 1N914, 75 PIV, switching diode D2 319 forward biased from pin; to 0.22 uF (50 volt) electrolytic capacitor C3 327 to ground 303; to 47K resistor R5 321 to the wiper of 20K, 15 turn, ¾ watt adjustable resistor R7 323, one end of which is open and the other end of which is connected to pin 7. Pin 7 in addition is connected to 33K resistor R4 313 to the wiper of 20K, 15 turn, ¾ watt adjustable resistor R6 315, one end of which is open and the other end of which is connected to the positive supply rail 302. Pin 3 is the output.

[0055] The square wave frequency and duty cycle produced by 555 Timer U2 215 are adjusted by 20K, 15 turn, ¾ watt adjustable resistors R6 315 and R7 323 in accordance with the following formulas:

[0056] t1 (output high)=0.693×(R4+R5+R6+R7)×C3

[0057] t2 (output low)=0.693×(R5+R7)×C3

[0058] T (total period)=t1+t2

[0059] f (frequency)=1/T

[0060] D (duty cycle)=(R5+R7)/( (R4+R6)+2×(R5+R7))

[0061] (Units: R-Ohms; C-Farads; t, T-Seconds, f-Hz.)

[0062] The exact frequency and duty cycle of this square wave varies with the battery voltage and precise component values The 60 Hz. and 50% duty cycle figures required for successful operation of the preferred embodiment are believed to be plus or minus 10%, based on the condition of the batteries, exact component characteristics and environmental factors such as ambient and operating temperature.

[0063] The 1.167 Hz (70 pulse per minute) timing circuit 240 is similar to that of circuit 210. The approximately 1.167 Hz. timer circuit 240 is based on a low power TLC 555 timer U3 341, set up as an astable multivibrator by connecting pins 2 (Trigger) and 6 (Threshold) together. Pin 1 is connected to ground 303. Pins 4 and 8 are connected to the positive supply rail 302. Pin 5 is connected to the midpoint of a voltage divider comprised of 1K resistor R14 347 from the positive supply and 2.2 K resistor R15 355 to ground 303. Pin 6 is in addition connected to 1N914, 75 PIV, switching diode D3 349 forward biased from pin 7; to 10.0 uF (16 volt) electrolytic capacitor C4 357 to ground 303; to 47K resistor R11 351 to the wiper of 20K, 15 turn, ¾ watt adjustable resistor R13 353, one end of which is open and the other end of which is connected to pin 7. Pin 7 in addition is connected to 33K resistor R10 343 to the wiper of 20K, 15 turn, ¾ watt adjustable resistor R12 345, one end of which is open and the other end of which is connected to the positive supply rail 302. Pin 3 is the output.

[0064] The output voltage of both TLC 555 timer circuits 210 and 240 is approximately 4 volts, which varies with battery supply voltage.

[0065] The approximately 1.667 Hz. signal is combined with the approximately 60 Hz. signal in AND gate 260 which consists of 330 Ohm input resistors R2 367 and R3 367, and MPS2907 PNP transistors Q1 280 and Q2 290. FIG. 4A shows the waveform output from AND gate 260.

[0066] From the output of the AND gate 260 is a 2.15K resistor R1 369 in series with 2 ma red light emitting diode (LED) D1 117 (Radio Shack 276-044 or equivalent) forward biased to ground 303. The LED is visible on the outside of housing 110, and is in the circuit merely to provide a visual indicator that the Battery SCPO is operating.

[0067] The remainder of the circuit consists of 8.2 mH inductor L2 371 (Miller 8230-18), 5.5-18 pF trimmer capacitor C2 372 (Sprague-Goodman GY A22000 or equivalent), quartz crystal X1 280 and treatment loop L1 120 to ground 303.

[0068] Crystal X1 280 is cut so as to have a base frequency in the 14.4 MHz. Range, and a third harmonic at one of the following frequencies: 43.351830±20 Hz., 43.351850±20 Hz., 43.351855±20 Hz and 43.351830±20 Hz. Quartz crystal 280 is obtained from International Crystal Manufactures, P.O. Box 26330, Oklahoma City, Okla. 73126, and selected with great care. Other sources for crystals that have been used include CTS Corporation, Knights Division, 400 East Reimann Ave., Sandwich Ill. 60548 (which is no longer in business) and NEL Frequency Controls, Inc. 357 Beloit Street, Burlington Wis.

[0069] Crystals are ordered approximately 25-50 at a time for each frequency, and are then individually tested on a Saunders Crystal Test System so as to allow selection of crystals with the desired frequency characteristics. For one representative crystal, driven with a reference frequency near the expected series resonance frequency, with a drive level of 2060 uWatts into 44 Ohms, with a 10 pF capacitative load, the results of this testing were as shown in Table 2. TABLE 2 Exemplary Crystal Measurements Parameter Description Value Fr(Hz.) Series resonant frequency 43,351,870 Hz. Co(pF) Shunt capacity 4.0 pF Rr(Ohms) Motional Resistance 18.2 Ohms Q(k) Quality factor 161.0 K C1(fF) Motional capacity 1.3 femtoFarads L(mH) Motional Inductance 10.7 mH Fl(Hz.) Loaded resonant frequency 43,353,820 Hz. Ts(ppm/pF) Trim sensitivity 3.2 ppm/pF PWR(uWatt) Power level 2740.0 uWatts

[0070] No oven is used in this device. Instead, the unit is turned on for 10 minutes before use, and used in a room at an ambient temperature of approximately 72 degrees Fahrenheit.

[0071] The output portion of the Battery SCPO involves a series LC circuit, a series crystal, and the treatment loop, which is another inductor. The large Motional Inductance of the crystal, and its very small Motional Capacitance, dominate the output circuit. This is driven by the square wave train coming out of AND gate 260. The modulation waveform output from AND gate 260, measured at the collector of transistor Q2 365, as shown in FIG. 4A, has a rise time of 18 nS and fall time approximately 120 nS. To a reasonable approximation, each 60 Hz. cycle in the modulation waveform represents a 4 volt step input with the aforementioned rise and fall times, into a series LC circuit with low series resistance. The high frequency components of the steep rise and fall of this square wave stimulates a ringing of the crystal at its characteristic base frequency and harmonics.

[0072] The actual output of the Battery SCPO at the point of input to Treatment Loop 120 can be observed on an oscilloscope, and visibly contains RF frequencies. This was observed using an SCPO constructed with a 43.351870 Hz. Crystal. When the signal from the SCPO was input into a spectrum analyzer, a −75 dB peak is observed at the 14.448461 MHz. base crystal frequency, and a −85 dB peak is seen at the 43.351870 MHz. third harmonic frequency of the crystal. An additional, weaker RF signal is observed at 43.420000 MHz. These various spectrum analyzer scans are shown in FIGS. 4B through 4F.

[0073] In sum, rather than using a conventional crystal oscillator circuit, the battery SCPO uses a crystal series driven by audio range square wave input pulses, in order to generate low power, yet precisely tuned, pulsed RF energy.

[0074] The treatment device is used by applying it, treatment loop down, to the subject's body in the area desired to be treated. The unit is left in place for approximately one hour at a time.

[0075] As indicated above, battery SCPOs have been built with crystals tuned to 43.351830±20 Hz., 43.351850±20 Hz., 43.351855±20 Hz and 43.351870±20 Hz. These frequencies were chosen because they are each believed to be useful for treating a plurality of illnesses, and because a multipurpose device is advantageous by reason of the inconvenience of changing crystals. However, there is no reason why this embodiment, would not be effective at any of the frequencies identified above as being therapeutically useful, as well as, with an appropriately tuned output element, if necessary, at any frequency found in the future to be therapeutically useful.

[0076] A parts list for the Battery SCPO is set forth in Table 3. TABLE 3 Parts List for Battery SCPO Ref. No. Description Source 110 SCPO Housing Fabricated-See text 114 Battery Holder Caltronics BH-124 115 “AA” Battery 4ea Wallgreens 1.5 V AA Ultra Alkaline or equiv. 117 Dl Indicator Light-2 mA Radio Shack 276-044 or equiv. LED Diode 120 Treatment Loop Fabricated-See text 127 Backing for treatment loop High Impact Styrene 0.080″ thick 280 Quartz Crystal ICM, CTS, or NEL-See text 311 U2-TLC 555 Timer Radio Shack 276-1723 or eguiv. 313 R4 33 K +/−5% 1/4 Watt Radio Shack 271-1341 or equiv. Carbon Resistor 315 R6 20 K 15 Turn 3/4 Watt Adj. Radio Shack 271-340 or equiv. Resistor 317 R9 1.0 K +/−5% 1/4 Watt Radio Shack 271-1321 or equiv. Carbon Resistor 319 D2 1N914 Switching Diode Radio Shack 276-1122 or equiv. 75 PIV 321 R5 47 K +/−5% 1/4 Watt Radio Shack 271-1342 or equiv. Carbon Resistor 323 R7 20 K 15 Turn 3/4 Watt Adj. Radio Shack 271-340 or equiv. Resistor 325 R8 2.2 K +/−5% 1/4 Watt Radio Shack 271-1325 or equiv. Carbon Resistor 327 C3 0.22 uf Electrolytic Radio Shack 272-1070 or equiv. Capacitor, 50 Volts 341 U3-TLC 555 Timer Radio Shack 276-1723 or equiv. 343 R10 33 K +/−5% 1/4 Watt Radio Shack 271-1341 or equiv. Carbon Resistor 345 R12 20 K 15 Turn 3/4 Watt Adj. Radio Shack 271-340 or equiv. Resistor 347 R14 1 K +/−5% 1/4 Watt Radio Shack 271-1321 or equiv. Carbon Resistor 349 D3 1N914 Switching Diode Radio Shack 276-1122 or equiv. 75 PIV 351 Rl1 47 K +/−5% 1/4 Watt Radio Shack 271-1342 or equiv. Carbon Resistor 353 R13 20 K 15 Turn 3/4 Watt Adj. Radio Shack 271-340 or equiv. Resistor 355 R15 2.2 K +/−5% 1/4 Watt Radio Shack 271-1325 or equiv. Carbon Resistor 357 C4 10 uf Electrolytic Capacitor, Radio Shack 272-1436 or equiv. 16 Volts 361 R2 330 Ohm +/−5% 1/4 Watt Radio Shack 271-1315 or equiv. Carbon Resistor 363 Q1 MP52907 PNP Transistor Radio Shack 276-2023 or equiv. 365 Q2 MPS2907 PNP Transistor Radio Shack 276-2023 or equiv. 367 R3 330 Ohm +/−5% 1/4 Watt Radio Shack 271-1315 or equiv. Carbon Resistor 369 R1 2.2 K +/−5% 1/4 Watt Radio Shack 271-1325 or equiv. Carbon Resistor 371 L2 8.2 uH Inductor Miller 8230-18 372 C2 5.5-18 pF Trimmer Capacitor Sprague-Goodman GYA22000 or equiv.

B. Generator Embodiment

[0077] The alternate embodiment of the treatment device is shown in FIG. 5. It employs a model 8662A frequency generator 500 manufactured by the Hewlett-Packard Company. Frequency generator 500 has a modulation input 520, to which is connected modulator unit 540, which provides an approximate 60 Hz square wave with an approximate 50% duty cycle, which is in turn gated with an approximately 1.167 (70 pulse per minute) square wave, also with an approximately 50% duty cycle.

[0078] The circuitry of modulator unit 540, which is more fully described below, is similar to that of the Battery SCPO, up to the point of AND gate.

[0079] As shown in FIG. 6, power is provided by a plug-in DC power module 550, Radio Shack Cat. No. 273-1455C or equivalent, which is rated at 9 volts D.C. at 0.3 amperes. The positive lead from the module is switched through power switch SW1 542, and then directed to a 7805 5 volt voltage regulator U1 605. The negative lead of the supply is attached to the unit's ground rail 603. Both the input and output of voltage regulator U1 605 is bypassed to ground by a 0.01 uF, 500 volt disc ceramic capacitor, C1 606 and C2 607. The output, a regulated 5 volts, is applied to positive supply rail 602.

[0080] The circuitry associated with the TLC 555 timers 611 and 641 is shown in FIG. 6, and is identical with the corresponding circuitry described above in the context of the Battery SCPO. The reference numerals “611” through “657” in FIG. 6 correspond to the identical elements “311” through “357” in FIG. 3.

[0081] The AND gate of the modulator for the Generator Embodiment is configured identically here as in the Battery SCPO. R2, R3, Q1 and Q2 (661, 663, 665, and 667) have the same values as in the SCPO circuit (361, 363, 365 and 367).

[0082] The LED indicator circuit R1 669 and D1 541 differs from its counterpart in the Battery SCPO in that R1 669 is 330 Ohms rather than 2.15K. The resistor difference is for the purpose of obtaining the proper LED brightness in each circuit.

[0083] Adjustable resistor R17 677 provides a voltage divider between positive rail 602 and ground 603. The wiper of R17 677 provides a positively offset “ground” for purposes of output to the HP 8662A. The reason for this is that the HP 8662A expects an DC signal for purposes of modulation, so this adjustment is provided to offset the output around “zero volts” as referenced to the chassis of the HP 8662A.

[0084] The output of AND gate at the emitter of Q2 665 is connected to 8.2 uH inductor L2 671 (Miller 8230-18). The resultant signal is bypassed to ground by a relatively large electrolytic capacitor, 1.5 uF, rated at 35 volts C5 673, and then passed to the center lead of output BNC connector 521.

[0085] The approximate modulation waveform produced by modulator unit 540 is shown in FIG. 7A. The rounding of the rise and fall of the waveform is the result of capacitor C5 673. The modulated waveform of one of the 60 Hz. cycles output by the HP 8662A is shown in FIG. 7B (the RF component in this figure is not drawn to scale). The output power of the frequency generator is less than 1 mw.

[0086] The output of frequency generator 500 is directed through a second BNC connector 531 connected to the panel of that instrument, and through a 50 Ohm, double-shielded coaxial cable 567 (RG 174 cable, Mouser #515-156-12 or equivalent). The coaxial cable is directed to a treatment loop 565 mounted on 2.0 mm. (0.080 inch) thick styrene sheet 566 which is laminated on stainless steel plate 560. The plate has dimensions of approximately 10.2 cm. by 6.35 cm. The treatment loop 565 is a 20 AWG solid copper wire approximately 60 cm. long, wound in a flat rectangular spiral comprising five turns, with a turn-to-turn spacing of approximately 3.175 mm. and overall dimensions of 2.858×5.258 cm. The center of the loop is soldered to the center lead of coaxial cable 567. Shield 863 of coaxial cable 567 is soldered to the back of plate 560 at solder point 861. The outer end of treatment loop 565 is grounded by being soldered at solder point 570 to the loop side of plate 560. (Use A and B figures to show both sides of the plate.

[0087] The signal from the frequency generator based embodiment of the treatment device is stronger electromagnetically than that output by battery operated device 100. It is also characterized by having only a single pure RF component at the desired frequency in the 43 MHz range. The treatment loop of generator embodiment is applied to the subject in the same manner as in the case of the battery powered embodiment.

[0088] A parts list for the Generator Embodiment is set forth in Table 4. TABLE 4 Parts List for Generator Embodiment Ref. No. Description Source 500 Hewlett-Packard 8662A Hewlett-Packard Company Frequency Generator 541 Dl Indicator Light-2 mA LED Radio Shack 276-044 or equiv. Diode 542 SWl Power Switch Radio Shack 275-612 or equiv. 550 9VDC Plug-In Power Supply Radio Shack 273-1455C or Module equiv. 560 Treatment Loop holder Fabricated-See text 565 Treatment Loop Fabricated-See text 567 Coaxial Cable, 50 ohm, RG174 cable Mouser Shielded #515-1156-12 605 U 1 7805 5 Volt Voltage Radio Shack 276-1770 or equiv. Regulator IC 606 0.01 uF Disc Ceramic Capacitor, Radio Shack 272-131 or equiv. 500 Volt 607 0.01 uF Disc Ceramic Capacitor, Radio Shack 272-131 or equiv. 500 Volt 611 U2-TLC 555 Timer Radio Shack 276-1723 or equiv. 613 R4 33 K +/−5% 1/4 Watt Radio Shack 271-1341 or equiv. Carbon Resistor 615 R6 20 K 15 Turn 3/4 Watt Adj. Radio Shack 271-340 or equiv. Resistor 617 R9 1.0 K +/−5% 1/4 Watt Radio Shack 271-1321 or equiv. Carbon Resistor 619 D2 1N914 Switching Diode Radio Shack 276-1122 or equiv. 75 PIV 621 R5 47 K +/−5% 1/4 Watt Radio Shack 271-1342 or equiv. Carbon Resistor 623 R7 20 K 15 Turn 3/4 Watt Adj. Radio Shack 271-340 or equiv Resistor 625 R8 2.2 K +/−5% 1/4 Watt Radio Shack 271-1325 or equiv. Carbon Resistor 627 C3 0.22 uf Electrolytic Radio Shack 272-1070 or equiv. Capacitor, 50 Volts 641 U3-TLC 555 Timer Radio Shack 276-1723 or equiv. 643 R10 33 K +/−5% 1/4 Watt Radio Shack 271-1341 or equiv Carbon Resistor 645 R12 20 K 15 Turn 3/4 Watt Adj. Radio Shack 271-340 or equiv. Resistor 647 R14 1 K +/−5% 1/4 Watt Radio Shack 271-1321 or equiv. Carbon Resistor 649 D3 1N914 Switching Diode Radio Shack 276-1122 or equiv. 75 PIV 651 Rl1 47 K +/−5% 1/4 Watt Radio Shack 271-1342 or equiv. Carbon Resistor 653 R13 20 K 15 Turn 3/4 Watt Adj. Radio Shack 271-340 or equiv. Resistor 655 R15 2.2 K +/−5% 1/4 Watt Radio Shack 271-1325 or equiv. Carbon Resistor 657 C4 1Ouf Electrolytic Capacitor, Radio Shack 272-1436 or equiv. 16 Volts 661 R2 330 Ohm +/−5% 1/4 Watt Radio Shack 271-1315 or equiv. Carbon Resistor 663 Q1 MPS2907 PNP Transistor Radio Shack 276-2023 or equiv. 665 02 MPS2907 PNF Transistor Radio Shack 276-2023 or equiv. 667 R3 330 Ohm +/−5% 1/4 Watt Radio Shack 271-1315 or equiv. Carbon Resistor 669 R1 330 Ohm +/−5% 1/4 Watt Radio Shack 271-1315 or equiv. Carbon Resistor 671 L2 8.2 uH Inductor Miller 8230-18 673 C5 1.47 uF Electrolytic Radio Shack 272-1433 & 1434 Capacitor, 35 Volts 677 R17 5 K Adj. 15 Turn 3/4 Watt Radio Shack 271-340 or equiv. Adj. Resistor

C. Alternative “Mouse SCPO” for Mouse Studies

[0089] For purposes of the mouse studies described below, an alternative embodiment of the treatment device was developed, hereinafter referred to as the “Test Embodiment”. The Mouse SCPO consisted of an apparatus similar to the battery SCPO described above, but without a battery compartment, and powered by an external AC power adapter. The power adapter used was the same Radio Shack adapter 550 used with the modulator for the Generator Embodiment. The power supply circuit in the Mouse SCPO was identical to that used in the modulator for the Generator Embodiment, comprising the 7805 regulator U1 605, and the two 0.01 uF bypass capacitors C1 606 and C2 607. In all other respects, the Mouse SCPO was as shown in FIGS. 1, 2 and 3, using the components listed in Table 4.

[0090] The feature lacked by the Mouse SCPO is the lack of restraint resulting from not being tethered by a wire. However, in the case of treating mice, this feature is irrelevant, since the mice must be immobilized for treatment in any event. On the other hand, the Test Embodiment had the advantage that it had no batteries to run low and to be checked and replaced.

D. Externally Pulsed Generator Embodiment

[0091] A further alternative embodiment of the treatment apparatus was developed, herein referred to as the “Externally Pulsed Generator.” The Externally Pulsed Modulator embodiment is identical to the apparatus shown in FIG. 5, except that (1) the modulator does not attach to the Modulator Input of the HP 8662A, but rather attaches directly via a BNC connector to the RF output of the HP 8662A, (2) the modulator externally modulates the RF signal and does not utilize the internal modulation circuitry provided by the HP 8662A; and (3) the cable used to connect the modulator to the Treatment Loop is a specific type of coaxial cable, i.e., a Hewlett-Packard 10501A, 50 Ohm coaxial cable approximately 1.1 meters long.

[0092] The modulator in the Externally Pulsed Generator embodiment contains a series solid state RF switch and associated connectors, which is pulsed by a pulsing circuit identical to that shown in FIG. 6, except that potentiometer R17 677 and capacitor C5 671 have been removed and the ground is taken from the main power supply ground rail 1303 (corresponding to rail 603 in PIG. 6). (Since there is no need to interface with the modulator input of the 8662A, there is no need for the floating ground used in the output circuit of FIG. 6.)

[0093] The schematic diagram in FIG. 36 shows the entire circuit of this external modulator. In FIG. 36A, which shows the exterior of the device, shielded box 3601 is attached to the end of modulator housing 3600. Male BNC connector 3610 attaches directly to the RF output of the 8662A. Female BNC connector 3620 attaches to the 10501 coax which in turn leads to the Treatment Loop. (Since this unit is a self-contained external modulator, it is necessary to turn off the modulation internal to the HP 8662A using the switch for that purpose on the control panel of the HP 8662A.)

[0094] In the RF switching circuit, the output of inductor L2 3671 is a 60 Hz/1.667 Hz. waveform 3640 (also as shown in FIG. 7A). This waveform shifts the bias on D4 3651 and D5 3652 so as to switch the RF applied to input 3653 in accordance with the pulses from L2 3671. In addition, inductor L2 3671 serves in this circuit as an RF choke keeping excessive RF from going back into the pulsing circuitry. TABLE 4A Additional Part for Externally Pulsed Generator Embodiment Ref. No. Description Source 500 C5 0.01 μf capacitor Radio Shack 272-131 or equiv. 541 C6 0.01 μf capacitor 542 R17 330 Ohm +/−5% ¼ Watt Radio Shack 275-1315 or equiv. Carbon Resistor 542 R18 330 Ohm +/−5% ¼ Watt Radio Shack 275-1315 or equiv Carbon Resistor 550 D4 1N914 Switching Diode Radio Shack 273-1122 or equiv. 75 PIV 560 Metal Box Any suitable supplier 565 Male BNC connector Any suitable supplier 567 Female BNC connector Any suitable supplier

3. EXPERIMENTAL PROCEDURE AND RESULTS

[0095] A controlled set of experiments were conducted during 1995 and 1996, to Jun. 25, 1996, to test the utility of the present invention with respect to the suppression and elimination of cancerous tumors, cysts, lesions, and neoplasia. The experiments were performed upon mice, by the topical application of electromagnetic (EMR) radiation at specific frequencies and intensities on a regular schedule, using the apparatus of the present invention as adapted for applying EMR to mice. We also present some additional measurements taken in 1997 with respect to one mouse that was treated using the Externally Pulsed Generator Embodiment.

[0096] “Suppression and elimination” means that tumors, etc. that do develop are smaller in size, occur relatively infrequently and are likely to disappear over time, as opposed to untreated tumors that are larger in size, occur more frequently and are unlikely to disappear before the death of the subject.

Use of JAX Mice as Experimental Subjects

[0097] The Jackson Laboratory at Bar Harbor, Me., 04609 supplies mice for scientific research. These special mice are “JAX Mice,” of a special inbred breed identified as C3H HeOuJ. These mice are highly abnormal, in that they are inherently very susceptible to adenocarcinoma of the mammary gland, due to the contributing factors of inherited genes, excessive hormonal stimulation, and the mouse mammary tumor virus, which is passed to the young through the mother's milk. The adenocarcinomas develop spontaneously in these mice, and the breed is characterized by a high incidence of mammary tumors by eight months of age. Our project has used “JAX Mice” type C3H HeOuJ throughout all of its research for treatment of mouse tumors, including all of the treated and control mice referred to herein.

[0098] The JAX C3H HeOuJ mice were selected in order to provide a sensitive animal model for testing anticancer treatments. The effectiveness of various treatments for such tumors is measured by determining improvements in lifespan or other physical characteristics, such as gross appearance, health status, and other related data, of groups that have received the treatment, as against untreated controls. This manner of testing using JAX mice is accepted as a valid animal model for determining the prospective utility of cancer treatments in humans.

[0099] In a memorandum dated Mar. 18, 1997, The Jackson Laboratory notified users of C3H/HeOuJ that it had observed an alteration over time of the development and incidence of tumors in this strain. Our experiments were primarily conducted in a much earlier time frame than that concerned in this memorandum, and we do not believe any of our experimental results were affected thereby.

Summary of Experimental Procedures and Results

[0100] “Control” and “treated” selections of JAX mice (10 mice per group) were observed over the duration of their lives. Control mice were not exposed to the treatment procedure at all. The treated mice were exposed to EMR at the skin layer.

[0101] The treatment given was exposure to electromagnetic radiation applied to the skin of the mouse, with the radiation held at a given frequency throughout the treatment. The duration of treatment was usually one-half to one hour, and during the treatment, the treating electrode was shielded from undue light and moving air currents.

[0102] The data from our experiments, discussed in detail below, show that:

[0103] 1. Treated mice live much longer than controls.

[0104] 2. The life spans of treated mice compare favorably with life spans of normal (i.e., non-JAX) mice.

[0105] 3. Treated mice have good health throughout their life.

[0106] 4. Prior treatment has prevented abdominal tumor development.

[0107] 5. When an abdominal tumor has been treated directly on the electrode it is caused to disappear.

[0108] 6. By contrast:

[0109] a) Tumors on control mice grow rapidly until death of the mouse,

[0110] b) And as tumors grow, a control mouse gains weight, its hematocrit decreases and its health fails rapidly until death.

[0111] Treatment of the particular mice herein discussed was by exposure of the JAX mice to radiation from an electrode which was energized by a low power source that was preset to provide frequencies of 43.351830 MHz, 43.351850 MHz and 43.351870 MHz. In some cases, an HP-8662A Signal Generator preset to these frequencies was used, equipped with a modulator (in all but the 1997 data, an internally coupled modulator), to provide approximately 1.667 and 60 Hz., approximately 50% duty cycle square wave pulse trains as previously described. In other cases, the same pulsed treatment frequencies were obtained with the “Mouse SCPO” embodiment described above, which contained its own modulator circuit, driving an internal quartz crystal.

[0112] The frequencies selected, as listed in the preceding paragraph, were based on prior experiments conducted over a period of many years, during which a large number of mice were treated under varying conditions and with various treatments. The three frequencies specified in the preceding paragraph are believed by the inventors to be among the most effective frequencies for treating a range of maladies. When using the Mouse SCPO embodiment, the treatment frequency used 69% of the time (659 hours out of a total of 950) was 43351870 Hz. When using the HP 8662A signal generator for treatment, many (35) different frequencies were used.

Treatment Procedures

[0113] One of the treated mice (OUJ-479) received treatments before a tumor appeared and lived and died tumor free.

[0114] Treatment of the remaining mice started as soon as a tumor reached 0.07″ in length, width, and height, corresponding to an ellipsoid having a volume of 0.0295 cubic cm. (0.00018 cubic inches). The treatments for all these ten mice were every day except Sunday. The treatment frequencies are limited to a few specific frequencies within a narrow range, and the intensities are normally set to 0 dBm into a 50 ohm load.

[0115] Due to variations among individual mice (as in other species, including humans), a treatment configuration that is effective for one subject doesn't always work for another. Frequencies of 43.351850 MHz and 43.351870 MHz were used for standard treatment on almost all of the mice. These frequencies have demonstrated good results. Treating mice with 43.351850 MHz from a signal generator and/or pulsed crystal, appears to clear up their secondary infections, and treating with 43.351870 MHz seems to restore their general health. All of the treated mice appeared to be very lively and have a very healthy skin and hair appearance. Of the mice listed below, all hematocrit values have stayed in the healthy range of 38% to 46%, and their weight basically stayed the same since they began treatment.

[0116] Hematocrits for both the treated and the control mice were measured in accordance with the following procedure. The hematocrit was taken once a week. The mouse was placed under a heat lamp for a few minutes to cause the veins in the tail to dilate, thus making it easier to extract the blood for the sample. The amount of blood taken was about one-half of the standard 75 mm long capillary tube. The capillary tubes containing the blood are spun in a Micro-Hematocrit Centrifuge, at its “number three” marking. The capillary tubes are removed and placed in the Micro-hematocrit Tube Reader, which gives the percent of red blood cells found in the sample.

[0117] We have observed that tumors that have reached 0.07″ in length, 0.07″ in width, 0.07″ in height are definitely a malignant growth, and benign or cystic lesions can be ruled out. Neoplasia measured under the agreed size are questionable. Almost all of the neoplasia encountered measured 0.07″, 0.07″, 0.07″ and above.

[0118] The treatments employed a variety of treatment electrodes and housings, as shown in FIG. 9. The preferred housing was the “E” housing shown in FIG. 9A, and the preferred electrodes were the “I” electrode associated with the Mouse SCPO, FIG. 9J, and the “F” electrode used with the Hewlett-Packard signal generator, FIG. 9B.

[0119] Tumors treated directly on the treatment electrode slowly regressed until they were gone. Tumors that were not on, or only partially on, the electrode showed a decrease in growth rate, but the tumor would steadily grow and not regress back The electrode was re-designed so that any tumor could be treated. The tumor must be directly on the electrode to receive the maximum treatment needed for complete regression of growth. Mice with lesions on their abdomen had direct contact with the electrode, and all completely regressed back to zero. We've had similar success with some mice with lesions on the neck, left leg, right neck, right side, etc.

[0120] Since mammary tumors occur spontaneously in these mice, some mice were also treated before any tumors appeared in the hope of preventing the inevitable fate of the cancerous C3H strain, which have an almost 100% occurrence rate. At present one of the mice lived out its life span tumor free and died of old age.

Treated Mice

[0121] The following describes our experimental results with respect to each individual treated mouse. For each mouse, there is a corresponding drawing showing where on the mouse tumors appeared, and in which the tumors are identified by a “tumor number” T-X, as well as a drawing reference numeral; a graph showing tumor volume in cubic inches vs. time in days; a graph showing mouse weight in grams and hematocrit readings vs. time in days; and an Appendix setting forth all experimental measurements taken with respect to the mouse.

[0122] Each tumor growth graph (FIGS. 10B, 11B, etc.) shows the size of each tumor, in cubic inches, on the mouse in question as a logarithmic function of days after the appearance of the subject's first tumor. Tumor volume, in cubic inches, was calculated based on the assumption that the tumor was approximately an ellipsoid, and had a volume equal to ½ length×½ width×height×2.094.

[0123] Each weight and hematocrit graph (FIGS. 10C, 11C, etc.) shows, in two separate plots, (a) the weight of the mouse, in grams, and (b) the subject's hematocrit values (percentage of red blood cells) as a linear function of days after the appearance of the subject's first tumor.

[0124] The detailed data collected with respect to each treated mouse is shown in tabular form in Appendices A-1, A-2, etc. attached hereto, and the data collected with respect to each control mouse is shown in tabular form in Appendices, B-1, B-2, etc. attached hereto. The data with respect to one mouse tested in 1997 is shown in tabular form in Appendix C.

Example 1—Treated Mouse OUJ456

[0125] TABLE 5 Treatment Summary for OUJ-456 Date of Birth 09/08/94 Date Died 08/04/95 Lived 310 days Treated 91 days Tumor measurements started 05/05/95 Tumor measurements taken for 91 days

[0126] This mouse lived 219 days before any tumor appeared. Notice (in FIG. 10B) that T-2 1002, which was hard to reach with our electrodes, grew, but at a slower rate than a typical control mouse. As will be seen from this and the other examples herein, treated mice live three times longer than controls after a tumor appears.

Example 2—Treated Mouse OUJ-470

[0127] TABLE 6 Treatment Summary for OUJ-470 Date of Birth 03/03/94 ate Died 07/30/95 Lived 515 days Treated 257 days Tumor measurements started 11/16/94 Tumor measurements taken for 257 days

[0128] This mouse lived 258 days before any tumor appeared. Notice (in FIG. 11B) that T-1 1101 appeared and went away at two different times. T-2 1102 appeared for a short period. T-3 1103 appeared when this mouse was 496 days old. This is one of the longest-lived mice in our experiments.

Example 3—Treated Mouse OUJ-471

[0129] TABLE 7 Treatment Summary for OUJ-471 Date of Birth 03/03/94 Date Died 07/20/95 Lived 504 days Treated 199 days Tumor measurements started 01/02/94 Tumor measurements taken for 199 days

[0130] This mouse lived 305 days before any tumor appeared. Notice that T-1 1201 and T-2 1202 appeared for a short period. Notice (in FIG. 12C) the steady weight at 30 grams and constant high hematocrit percentage readings. This was also one of our longest-lived mice.

Example 4—Treated Mouse OUJ-473

[0131] TABLE 8 Treatment Summary for OUJ-473 Date of Birth 03/03/94 Date Died 07/28/95 Lived 514 days Treated 211 days Tumor measurements started 12/29/94 Tumor measurements taken for 211 days

[0132] As an experiment, we treated this mouse before any tumors appeared. This mouse never developed any tumors (FIG. 13B). She lived 303 days before we started treatments. Notice (in FIG. 13C) the steady weight at 28 grams. This was also one of our longest-lived mice.

Example 5—Treated Mouse OUJ-475

[0133] TABLE 9 Treatment Summary for OUJ-475 Date of Birth 03/03/94 Date Died 07/28/95 Lived 514 days Treated 256 days Tumor measurements started 11/14/94 Tumor measurements taken for 256 days

[0134] This mouse lived 258 days before any tumor appeared. Notice (FIG. 14B) that T-1 1401 and T-2 1402 appeared for a short period. Notice (FIG. 13C) the steady weight at 30 grams and quite-constant high hematocrit percentage readings. This was also one of our longest-lived mice.

Example 6—Treated Mouse OUJ-496

[0135] TABLE 10 Treatment Summary for OUJ-496 Date of Birth: 12/21/94 Date Died: 01/05/96 Lived: 380 days Treated: 113 days Tumor measurements 09/15/95 started: Tumor measurements taken 113 days for:

[0136] This mouse lived 267 days before any tumor appeared. Notice (FIG. 15B) that T-1 1501 and T-5 1505 appeared and left. Notice (FIG. 15C) the steady weight at 30 grams and high hematocrit percentage readings. Even with all these tumors, this mouse stayed healthy until the end and lived a long time.

Example 7—Treated Mouse OUJ-506

[0137] TABLE 11 Treatment Summary for OUJ-506 Date of Birth: 01/05/95 Still living: 06/25/96 Lived: 537 days Treated (and/or took data): 250 days Tumor measurements 10/19/95 started: Tumor measurements taken 250 days for:

[0138] This mouse lived 287 days before any tumor appeared. Notice (FIG. 16B) that T-1 1601, T-2 1602, and T-3 1603 appeared for a short period. After 170 days, T-2 1602 reappeared. Notice (FIG. 16C) the constant high hematocrit percentage readings. This was our longest-lived mouse, and it had a long healthy life.

Example 8—Treated Mouse OUJ-516

[0139] TABLE 12 Treatment Summary for OUJ-516 Date of Birth: 02/02/95 Date Died: 03/26/96 Lived: 418 days Treated: 240 days Tumor measurements 07/31/95 started: Tumor measurements taken 240 days for:

[0140] This mouse had a record number of tumors, many of which were not on the abdomen (FIG. 17A). After treatment all tumors disappeared except T5 1705, T7 1707, T8 1708, and T9 1709 (FIG. 17B). In spite of the large number of tumors, she lived 418 days.

Example 9 - Treated Mouse OUJ-526

[0141] TABLE 13 Treatment Summary for OUJ-526 Date of Birth: 02/02/95 Date Died: 04/12/96 Lived: 435 days Treated: 168 days Tumor measurements 10/28/95 started: Tumor measurements taken 168 days for:

[0142] This mouse had three tumors which disappeared and never returned (FIG. 18B). She lived 267 days before any tumor appeared. T4 1804 and T5 1805 grew together as one tumor. Hematocrit percent (FIG. 18C) stayed quite high throughout her life.

Example 10—Treated Mouse OUJ-650

[0143] TABLE 14 Treatment Summary for OUJ-650 Date of Birth: 04/04/95 Still living: 06/25/96 Lived: 448 days Treated: 195 days Tumor measurements 12/13/95 started: Tumor measurements taken 195 days for:

[0144] This mouse had three tumors, all of which disappeared and never re-appeared (FIG. 19B). Her hematocrit percent and remained high and her weight stayed constant throughout the measurement period (FIG. 19C).

Control Mice

[0145] The controls listed below all had spontaneous occurrences of multiple tumors that arose in various areas of the mammary gland region, and also had a very short survival time once the tumors appeared, usually around a two-month period.

[0146] None of the control mice in this study received EMR treatments or any other type of intervention methods. Daily weight and tumor measurements and observations were noted, as well as hematocrits to indicate the mouse's present health status at the time. These non-treated mice appeared to be in excellent health and appearance when the tumor remained small and didn't metastasize, but as the malignancy progressed and spread to other tissues, the effects on the mouse were readily seen.

[0147] The tumor measurements showed a rapid increase in tumor size that continuously rose almost every day, accompanied with a steady gain in weight, especially, with the arrival of new neoplasms. The hematrocrit steadily lowers with the increase in tumor measurements. Other side-effects were also observed in the controls, such as, the coat began to show a rougher appearance, the back bone protruded out, they appeared to be malnourished, and the normal curiosity and physical activity seen in healthy mice were absent. The neoplasms' appearance also changed once the tumor reached a certain size, usually around 1.5 cm. in diameter and up. They usually would start to appear red and puffy, which would deepen in color showing areas of purple and black sores, which eventually ulcerated with severe bleeding. Some of the mice also appeared to get secondary infections once the tumor ulcerated, accompanied by the draining of clear fluid and WBC present in the wound. When the tumor reached a diameter of 1.8 cm., and the hematocrit value was 25% or lower, the mouse usually died within a couple of days.

[0148] As will be illustrated by the experimental data that follows, the characteristics of all control mice observed in the lab included the following: a rapid growth rate of tumors shown in the increasing size measurements and weight gain; metastasis; and continual decrease in hematocrit with the increasing tumor measurements. All the above symptoms affect the mouse's gross appearance, tumor appearance and shortened survival span once the tumors appear. This is reflected in the data that follows in the controls' rate of growth, and their decrease in hematocrit and length of survival period.

Example 11—Control Mouse A-486

[0149] TABLE 15 Summary for A-486 Date of Birth: 04/04/95 Date died: 06/25/96 Lived: 448 days Treated: Not treated Tumor measurements 08/09/95 started: Tumor measurements taken 97 days for:

[0150] This mouse had one tumor which grew very rapidly to a large size (FIG. 20B). She had another tumor which appeared for 8 days. Her weight started to increase near the end, and the low hematocrit readings indicated a poor general health (FIG. 20C).

Example 12—Control Mouse A-488

[0151] TABLE 16 Summary for A-488 Date of Birth: 11/28/94 Date died: 11/13/95 Lived: 350 days Treated: Not treated Tumor measurements 07/20/95 started: Tumor measurements taken 116 days for:

[0152] This mouse had one tumor (T1 2101) which didn't change much for forty days then grew rapidly (FIG. 21B). T-2 2102 came in and left after 32 days. T-3 2103 stayed constant in size for about 90 days, then grew rapidly.

Example 13—Control Mouse A-490

[0153] TABLE 17 Summary for A-490 Date of Birth: 12/19/94 Date died: 11/29/95 Lived: 345 days Treated: Not treated Tumor measurements 10/11/95 started: Tumor measurements taken 50 days for:

[0154] This mouse had four rapidly growing tumors and lived only fifty days after the first tumor appeared (FIG. 22B). After 20 days her weight increased and hematocrit reading steadily dropped (FIG. 22C).

Example 14—Control Mouse A-492

[0155] TABLE 18 Summary for A-492 Date of Birth: 12/19/94 Date died: 12/29/95 Lived: 375 days Treated: Not treated Tumor measurements 09/15/95 started: Tumor measurements taken 105 days for:

[0156] At 375 days, this is the longest lived control mouse. (Nine of our ten treated mice lived longer.) She had two tumors that left (FIG. 23B). But, after thirty days, T3 2303 and T4 2304 appeared and started to grow very rapidly. Her hematocrits dropped rapidly after 70 days of measurements (FIG. 23C).

Example 15—Control Mouse A-500

[0157] TABLE 19 Summary for A-500 Date of Birth: 01/04/95 Date died: 10/11/95 Lived: 280 days Treated: Not heated Tumor measurements 09/15/95 started: Tumor measurements taken 26 days for:

[0158] This mouse did not live very long and was observed only twenty-six days then she died. Tumors grew rapidly (FIG. 24B) and hematocrits were quite low (FIG. 24C).

Example 16—Control Mouse A-538

[0159] TABLE 20 Summary for A-538 Date of Birth: 03/24/95 Date died: 01/15/96 Lived: 297 days Treated: Not treated Tumor measurements 10/19/95 started: Tumor measurements taken  88 days for:

[0160] This mouse had three large tumors (FIG. 25B) and rapid weight increase and very low hematocrit percent readings (FIG. 25C). This mouse also did not live very long and was quite unhealthy.

Example 17—Control Mouse A-540

[0161] TABLE 21 Summary for A-540 Date of Birth: 03/25/95 Date died: 01/02/96 Lived: 283 days Treated: Not treated Tumor measurements 11/15/95 started: Tumor measurements taken  48 days for:

[0162] This mouse had one tumor that grew to a large size and grew fast (FIG. 26B). Low hematocrits caused this mouse to die in a short period (FIG. 26C).

Example 18—Control Mouse A-542

[0163] TABLE 22 Summary for A-542 Date of Birth: 03/25/95 Date died: 01/18/96 Lived: 299 days Treated: Not treated Tumor measurements 11/27/95 started: Tumor measurements taken  52 days for:

[0164] This mouse had two tumors that grew to a large size and grew fast (FIG. 27B). Weight continued to increase as the tumors grew (FIG. 27C). A tumor size of 0.1 to 0.5 cubic inches on a mouse this small is quite a burden for the mouse. They do not survive for long with tumors that size.

Example 19—Control Mouse A-592

[0165] TABLE 23 Summary for A-592 Date of Birth: 06/27/95 Date died: 02/14/96 Lived: 232 days Treated: Not heated Tumor measurements 01/19/96 started: Tumor measurements taken  26 days for:

[0166] This mouse had one tumor that grew to a one cubic inch in size and grew fast (FIG. 28B). Rapid decline in hematocrits caused this mouse to die in a short period (FIG. 28C). Notice the rapid increase in weight: the mouse nearly doubled in weight in twenty days. This was a very short-lived mouse.

Example 20—Control Mouse A-594

[0167] TABLE 24 Summary for A-594 Date of Birth: 06/27/95 Date died: 02/15/96 Lived: 233 days Treated: Not treated Tumor measurements 01/12/96 started: Tumor measurements taken  34 days for:

[0168] This mouse also had one tumor that grew to a large size and grew fast (FIG. 29B). Rapidly declining hematocrits caused this mouse to die in a short period (FIG. 29C). This is one of the shortest-lived control mice of the group.

Experimental Conclusions

[0169] Our principal conclusion, based on the experiments described above, is that the cancer-prone JAX mice benefited considerably from the therapeutic apparatus and method of the present invention. The subsidiary experimental conclusions that support this assertion are as follows:

1. Total Days of Life: Treated Mice Live 50% Longer

[0170] The bar-graphs in FIG. 30 show that the treated mice lived approximately 50% longer on average than the controls. Each bar indicates: Days of Waiting 3001, Days of Treatment (or Measurement) 3002, 3003, and Total Days Of Life 3004.

[0171] The data underlying FIG. 30 (as well as FIGS. 31 and 32, discussed below) is presented below in tabular form. TABLE 25 Days of Life, Measurement, and Number of Tumors NON MEASURED MEASURED QTY OF SUBJECT DAYS DAYS TUMORS TOTAL LIFE OUJ-456 219  91 2 310 OUJ-496 268 112 6 380 OUJ-650 253 195 3 392 OUJ-516 179 239 9 418 OUJ-526 268 167 5 435 OUJ-506 287 250 5 481 OUJ-471 305 199 2 504 OUJ-473 301 211 0 512 OUJ-475 256 256 2 512 OUJ-470 258 256 3 514 Totals: 2594  1976  37  4,458   A-592 206  26 3 232 A-594 199  34 1 233 A-500 254  26 3 280 A-540 235  48 1 283 A-538 209  88 3 297 A-542 247  52 2 299 A-490 296  49 4 345 A-488 234 116 4 350 A-486 255  97 2 352 A-492 270 105 4 375 Totals: 2405  641 27  3,046  

2. Starting Treatment After First Tumor Appears: Treated Mice Live More than 300% Longer

[0172]FIG. 31 shows that after the first tumor appeared, the treated mice lived longer than the control mice. The bars in these graphs represent Days of Treatment for treated mice or Days of Measurement for control mice. The data underlying FIG. 31 is set forth in Table 25 above.

3. The Treated Mice Had More Tumors (by 37%), But They Lived Longer

[0173]FIG. 32 shows the number of tumors that developed in each mouse. It must be noted that even though there were 37% more tumors in the treated mice, they lived longer than the controls. The data underlying FIG. 32 is set forth in Table 25 above.

4. Tumors that Appeared were Five Times More Likely to Disappear in the Treated Mice than in the Controls

[0174]FIG. 33 shows the total number of tumors in each mouse, and those tumors that disappeared or were cured and the remaining tumors at the death of each mouse. (Note: OUJ-506 and OUJ-650 were still living as of Jun. 25, 1996, when this data was compiled.)

[0175] The data underlying FIG. 33 is set forth in Table 26 below. TABLE 26 Tumors That Disappeared MEAS- REMAIN- CURED/ NON URED ING GONE TOTAL MEASURED SUBJECT DAYS TUMORS TUMORS LIFE DAYS OUJ-456  91 1 1 310 219 OUJ-496 112 3 3 380 268 OUJ-650 195 0 3 448 253 OUJ-516 239 4 5 418 179 OUJ-526 167 2 3 435 268 OUJ-506 250 2 3 537 287 OUJ-471 199 0 2 504 305 OUJ-473 211 0 0 512 301 OUJ-475 256 0 2 512 256 OUJ-470 256 1 2 514 258 Totals: 1976  13  24  4,570   2594  A-592  26 3 0 232 206 A-594  34 1 0 233 199 A-500  26 3 0 280 254 A-540  48 1 0 283 235 A-538  88 3 0 297 209 A-542  52 2 0 299 247 A-490  49 4 0 345 296 A-488 116 3 1 350 234 A-486  97 1 1 352 255 A-492 105 2 2 375 270 Totals: 641 23  4 3,046   2405 

5. The Weight of the Treated Mice Remained Stable, Whereas the Control Mice Markedly Gained Weight

[0176]FIG. 34 shows that the treated mice maintain their weight on average, while the control mice gain considerable weight due to tumor growth. (Note: The weight change shown is the last 10 day weight average minus the first 10 day weight average of each mouse.)

[0177] The data underlying FIG. 34 is set forth in Table 27 below. TABLE 27 Comparative Weight Changes Weight Change Treated Mouse OUJ-456 5.85 OUJ-526 2.37 OUJ-470 1.31 OUJ-471 −0.15 OUJ-473 −1.36 OUJ-475 −2.22 OUJ-506 −0.66 OUJ-650 −0.15 OUJ-516 0.07 OUJ-496 −4.92 Totals: 0.14 Control Mouse A-592 20.31 A-538 15.42 A-490 14.32 A-542 9.97 A-486 6.54 A-540 6.15 A-492 3.98 A-500 0.02 A-488 −1.73 A-594 −4.92 Totals: 70.06

6. The Control Mice Had More Large Tumors

[0178]FIG. 35 shows the maximum sizes of each tumor on the twenty different mice. Some of these tumors disappeared. The vertical scale is tumor size in cubic inches. There were 37 treated and 27 control tumors but this graph shows the 27 largest treated tumors and all 27 control tumors.

[0179] The data underlying FIG. 35 is set forth in Tables 28A and B below. TABLE 28A Comparison of Maximum Tumor Size (in cubic inches) Treated Subject Tumor 1 Tumor 2 Tumor 3 Tumor 4 Tumor 5 Tumor 6 Tumor 7 Tumor 8 Tumor 9 OUJ-456 0.00001413 0.27320000 OUJ-470 0.00017960 0.00001413 0.00954900 OUJ-471 0.00026180 0.00009161 OUJ-473 OUJ-475 0.00001413 0.00036650 OUJ-496 0.00117800 0.03799000 0.00633200 0.01099000 0.00015390 0.00029680 OUJ-506 0.00001413 0.01866000 0.00001413 0.00017960 0.01682000 OUJ-516 0.00001413 0.00017960 0.00006544 0.00653300 0.08179000 0.00048370 0.03624000 0.05560000 0.17990000 OUJ-526 0.00001413 0.00082920 0.00006544 0.06579000 0.00533600 OUJ-650 0.00241900 0.00006544 0.00006544 Total 0.00410800 0.33140000 0.01609000 0.08349000 0.10410000 0.00078050 0.03624000 0.05560000 0.17990000 Average 0.00045650 0.03682000 0.00268200 0.02087000 0.02603000 0.00039030 0.03624000 0.05560000 0.17990000

[0180] TABLE 28B Comparison of Maximum Tumor Size (in cubic inches) Control Subject Tumor 1 Tumor 2 Tumor 3 Tumor 4 A-486 0.43920000 0.00001413 A-488 0.41790000 0.00619300 0.00762200 0.01493000 A-490 0.20800000 0.47080000 0.04913000 0.02954000 A-492 0.00052350 0.00006544 0.10690000 0.16280000 A-500 0.06478000 0.04252000 0.20560000 A-538 0.56350000 0.32310000 0.03216000 A-540 0.39520000 A-542 0.36820000 0.13700000 A-592 0.81920000 0.00419200 0.01504000 A-594 0.19090000 Total 3.46700000 0.98380000 0.41640000 0.20730000 Average 0.34670000 0.12300000 0.06940000 0.06910000

Test of Externally Pulsed Generator

[0181]FIG. 37 shows the results of treating mouse OUJ-738 in 1997 with the Externally Pulsed Generator embodiment. Treatment was with the HP 8662A frequency generator externally modulated with the modulator shown in FIG. 36, coupled to a treatment loop as shown in FIGS. 8A and 8B deployed in the “E” housing shown in FIG. 9A. The corresponding experimental data is shown in Appendix C.

[0182]FIG. 37A shows that a single tumor T1 3701 developed on this mouse in the left arm position. This position is difficult to treat because it is out of the way and as a consequence it is difficult to position the treatment electrode close to the tumor. Nevertheless, the results with this mouse were extremely good for the period of testing. As shown in FIG. 37B, the tumor stayed small for the entire period, and as shown in FIG. 37C, the weight was stable and the hematocrits remained high. The data extends up to a few days prior to the filing of this application, and at the end of this period the mouse was alive and healthy.

[0183] In addition, data were compiled in 1997 with respect to tumors that disappeared after treatment with the generator embodiment. This data, which otherwise appears in the Figures hereto, is as follows: TABLE 29 Disappearance of Tumors on Mice Treated with HP 8662A Frequency Generator Embodiment Treated Tumor Tumor Tumor Tumor Tumor Tumor Mouse # 1 2 3 4 5 6 OUJ-650 Yes Yes Yes OUJ-526 Yes Yes Yes OUJ-516 Yes Yes Yes Yes Yes OUJ-506 Yes Yes Yes Yes OUJ-496 Yes Yes OUJ-471 Yes Yes OUJ-470 Yes Yes OUJ-456 Yes

[0184] It is apparent from the foregoing that a new treatment has been developed which has shown great effectiveness in treating cancer and other illnesses in laboratory mice and is believed to be a promising treatment for humans. While only presently preferred embodiments have been described in detail, it will be apparent to those skilled in the art that certain changes and modifications can be made without departing from the scope of the invention, as defined in the following claims.

APPENDICES A1-A10 TREATED MOUSE DATA

[0185] Index (Pages numbered on back) Appendix Subject Pages A1 OUJ 456 48-49 A2 OUJ 470 50-55 A3 OUJ 471 56-59 A4 OUJ 473 60-63 A5 OUJ 475 64-69 A6 OUJ 496 70-71 A7 OUJ 506 72-75 A8 OUJ 516 76-83 A9 OUJ 526 84-91  A10 OUJ 650 92-93

[0186]

APPENDICES B1-B10 CONTROL MOUSE DATA

[0187] Index (Pages numbered on back) Appendix Subject Pages B1 A 486 95-97 B2 A 488  98-100 B3 A 490 101-102 B4 A 492 103-105 B5 A 500 106 B6 A 538 107-108 B7 A 540 109-110 B8 A 542 111-112 B9 A 592 113  B10 A 594 114

[0188] A-486 DOB Nov. 27, 1994 A-486 LT ARM T-1 LT INR LEG T-2 WEIGHT HEMA- DAY DATE X Y Z EVOL X Y Z EVOL GRAMS TOCRIT  1  9-Aug 0.050 0.050 0.050 .00007 .00000 28.78  2 10-Aug 0.050 0.050 0.050 .00007 .00000 28.31  3 11-Aug 0.060 0.060 0.060 .00011 .00000 29.08  4 12-Aug 0.060 0.060 0.060 .00011 .00000 29.08  5 13-Aug 0.070 0.070 0.070 .00018 .00000 28.99  6 14-Aug 0.080 0.080 0.070 .00023 .00000 28.89  7 15-Aug 0.080 0.080 0.070 .00023 .00000 28.68  8 16-Aug 0.080 0.080 0.070 .00023 .00000 28.86  9 17-Aug 0.080 0.080 0.070 .00023 .00000 28.85 10 18-Aug 0.080 0.080 0.060 .00020 .00000 28.83 11 19-Aug 0.080 0.080 0.060 .00020 .00000 28.82 12 20-Aug 0.080 0.080 0.060 .00020 .00000 28.80 13 21-Aug 0.080 0.080 0.050 .00017 .00000 28.79 14 22-Aug 0.080 0.080 0.050 .00017 .00000 28.59 15 23-Aug 0.080 0.080 0.050 .00017 .00000 28.65 16 24-Aug 0.080 0.080 0.050 .00017 .00000 28.75 17 25-Aug 0.080 0.080 0.050 .00017 .00000 28.76 18 26-Aug 0.090 0.090 0.050 .00021 .00000 31.66 19 27-Aug 0.100 0.100 0.050 .00026 .00000 30.83 20 28-Aug 0.100 0.100 0.050 .00026 .00000 29.99 21 29-Aug 0.110 0.110 0.050 .00032 .00000 29.16 22 30-Aug 0.110 0.110 0.050 .00032 .00000 28.32 23 31-Aug 0.124 0.126 0.055 .00053 .00000 28.36 24  1-Sep 0.139 0.141 0.080 .00082 .00000 28.41 25  2-Sep 0.153 0.157 0.095 .00119 .00000 28.45 26  3-Sep 0.167 0.173 0.110 .00166 .00000 28.50 27  4-Sep 0.181 0.189 0.125 .00224 .00000 28.54 28  5-Sep 0.196 0.204 0.140 .00293 .00000 28.59 29  6-Sep 0.210 0.220 0.155 .00375 .00000 26.63 30  7-Sep 0.224 0.236 0.170 .00470 .00000 28.68 31  8-Sep 0.239 0.251 0.185 .00581 .00000 28.72 32  9-Sep 0.253 0.267 0.200 .00707 .00000 28.76 33 10-Sep 0.267 0.283 0.215 .00850 .00000 28.81 34 11-Sep 0.281 0.299 0.230 .01012 .00000 28.85 35 12-Sep 0.296 0.314 0.245 .01192 .00000 28.90 36 13-Sep 0.310 0.330 0.260 .01392 .00000 28.94 37 14-Sep 0.300 0.360 0.270 .01527 .00000 28.66 38 15-Sep 0.200 0.200 0.100 .00209 .00000 28.78 39 16-Sep 0.280 0.400 0.160 .00938 .00000 28.98 40 17-Sep 0.220 0.250 0.230 .00662 .00000 29.86 41 18-Sep 0.390 0.500 0.290 .02960 .00000 29.83 42 19-Sep 0.400 0.510 0.290 .03097 .00000 30.41 43 20-Sep 0.430 0.450 0.340 .03444 .00000 30.78 44 21-Sep 0.460 0.450 0.350 .03793 .00000 29.51 45 22-Sep 0.460 0.470 0.400 .04527 .00000 30.27 46 23-Sep 0.460 0.480 0.430 .04970 .00000 30.12 47 24-Sep 0.460 0.480 0.430 .04970 .00000 29.59 48 25-Sep 0.470 0.480 0.430 .05078 .00000 29.21 49 26-Sep 0.470 0.500 0.470 .05782 .00000 30.47 50 27-Sep 0.490 0.540 0.480 .06649 .00000 30.21 51 28-Sep 0.490 0.570 0.530 .07749 .00000 29.77 52 29-Sep 0.500 0.570 0.500 .07460 .00000 30.29 53 30-Sep 0.510 0.570 0.500 .07609 .00000 30.23 54  1-Oct 0.530 0.580 0.500 .08046 .00000 30.15 55  2-Oct 0.540 0.580 0.500 .08198 .00000 30.09 41 56  3-Oct 0.560 0.570 0.480 .08021 .00000 29.98 57  4-Oct 0.560 0.580 0.520 .08842 .00000 31.33 58  5-Oct 0.580 0.630 0.520 .09947 0.030 0.030 0.030 .00001 30.97 59  6-Oct 0.590 0.640 0.550 .10872 0.030 0.030 0.030 .00001 31.42 60  7-Oct 0.600 0.640 0.560 .11257 0.030 0.030 0.030 .00001 31.15 61  8-Oct 0.600 0.640 0.560 .11257 0.030 0.030 0.030 .00001 30.95 62  9-Oct 0.610 0.640 0.570 .11649 0.030 0.030 0.030 .00001 30.71 63 10-Oct 0.680 0.660 0.570 .12292 0.030 0.030 0.030 .00001 32.67 30 64 11-Oct 0.700 0.690 0.610 .15424 0.030 0.030 0.030 .00001 31.88 65 12-Oct 0.730 0.720 0.640 .17610 0.010 0.010 0.010 .00000 31.52 66 13-Oct 0.680 0.760 0.670 .18127 0.010 0.010 0.010 .00000 32.26 67 14-Oct 0.700 0.780 0.670 .19151 .00000 32.28 68 15-Oct 0.720 0.800 0.670 .20203 .00000 32.30 69 16-Oct 0.730 0.620 0.670 .20996 .00000 32.31 70 17-Oct 0.780 0.820 0.660 .22099 .00000 33.40 71 18-Oct 0.800 0.780 0.530 .17313 .00000 28.67 72 19-Oct 0.740 0.740 0.540 .15480 .00000 28.94 73 20-Oct 0.750 0.760 0.530 .15815 .00000 29.96 74 21-Oct 0.750 0.760 0.530 .15815 .00000 29.96 75 22-Oct 0.790 0.770 0.550 .17514 .00000 30.90 76 23-Oct 0.800 0.790 0.560 .18528 .00000 31.45 77 24-Oct 0.800 0.810 0.560 .18997 .00000 31.85 78 25-Oct 0.810 0.820 0.560 .19472 .00000 32.22 79 26-Oct 0.800 0.610 0.600 .20354 .00000 30.64 80 27-Oct 0.820 0.840 0.630 .22717 .00000 30.44 20 81 28-Oct 0.860 0.840 0.630 .23825 .00000 31.15 82 29-Oct 0.900 0.850 0.630 .25230 .00000 31.81 83 30-Oct 0.960 0.850 0.630 .26912 .00000 32.23 25 84 31-Oct 0.940 0.880 0.650 .28148 .00000 32.04 85  1-Nov 0.940 0.870 0.680 .29112 .00000 33.04 86  2-Nov 0.960 0.930 0.700 .32717 .00000 34.56 87  3-Nov 0.950 0.960 0.680 .32465 .00000 34.58 88  4-Nov 0.960 0.980 0.680 .33491 .00000 35.50 89  5-Nov 0.970 1.000 0.680 .34530 .00000 36.50 90  6-Nov 0.980 1.020 0.680 .35584 .00000 37.17 91  7-Nov 0.980 1.090 0.720 .40263 .00000 36.89 92  8-Nov 0.980 1.060 0.780 .42417 .00000 37.18 32 93  9-Nov 0.980 1.070 0.800 .43915 .00000 34.57 94 10-Nov 1.030 1.070 0.660 .38079 .00000 34.95 95 11-Nov 1.040 1.090 0.670 .39760 .00000 34.36 96 12-Nov 1.050 1.110 0.670 .40879 .00000 33.78 97 13-Nov 1.060 1.130 0.680 .42639 .00000 33.19 25 98 14-Nov Died Nov. 14 1995 #VALUE! Died Nov. 14 1995 #VALUE! 99 T-1 AVERAGE GROWTH T-2 AVERAGE GROWTH 100  0.486 0.505 0.380 0.112 0.026 0.026 0.026 0.000

[0189] DAY DATE X Y Z X Y Z X Y Z DOB 11/26/94 A-488 LT SIDE T-1 EVOL A-488 LT NECK T-2 EVOL A-488 LT BOTTOM T-3 EVOL 1 7/20/95 0 050 0 050 0 050 .00007 .00000 .00000 2 7/21/95 0.050 0.050 0.050 .00007 0.050 0.050 0.050 .00007 .00000 3 7/22/95 0.060 0.060 0.060 .00011 0.060 0.060 0.060 .00011 .00000 4 7/23/95 0.070 0.070 0.070 .00018 0.070 0.070 0.070 .00018 .00000 5 7/24/95 0.070 0.070 0.070 .00018 0.070 0.070 0.070 .00018 .00000 6 7/26/95 0.070 0.070 0.070 .00018 0.080 0.080 0.080 .00027 .00000 7 7/26/95 0.070 0.070 0.070 .00018 0.080 0.080 0.080 .00027 .00000 8 7/27/95 0.070 0.070 0.070 .00018 0.100 0.100 0.100 .00052 0.070 0.070 0.070 .00018 9 7/28/95 0.070 0.070 0.050 .00013 0.100 0.100 0.070 .00037 0.070 0.070 0.070 .00018 10 7/29/95 0.070 0.070 0.050 .00013 0.100 0.100 0.070 .00037 0.070 0.070 0.070 .00018 11 7/30/95 0.070 0.070 0.050 .00013 0.100 0.100 0.070 .00037 0.070 0.070 0.070 .00018 12 7/31/95 0.070 0.070 0.050 .00013 0.100 0.100 0.070 .00037 0.070 0.070 0.070 .00018 13 8/1/95 0.070 0.070 0.050 .00013 0.100 0.100 0.070 .00037 0.070 0.070 0.070 .00018 14 8/2/95 0.070 0.070 0.050 .00013 0.100 0.100 0.070 .00037 0.070 0.070 0.070 .00018 15 8/2/95 0.070 0.070 0.050 .00013 0.100 0.100 0.070 .00037 0.070 0.070 0.070 .00018 16 8/4/95 0.070 0.070 0.050 .00013 0.100 0.100 0.050 .00026 0.070 0.070 0.070 .00018 17 8/5/95 0.070 0.070 0.050 .00013 0.100 0.100 0.050 .00026 0.070 0.070 0.070 .00018 18 8/6/95 0.070 0.070 0.050 .00013 0.100 0.100 0.050 .00026 0.070 0.070 0.070 .00018 19 8/7/95 0.070 0.070 0.050 .00013 0.130 0.130 0.070 .00062 0.120 0.120 0.070 .00053 20 8/8/95 0.070 0.070 0.050 .00013 0.130 0.130 0.070 .00062 0.100 0.100 0.070 .00037 21 8/9/95 0.070 0.070 0.050 .00013 0.130 0.130 0.070 .00062 0.100 0.100 0.070 .00037 22 8/10/95 0.070 0.070 0.050 .00013 0.130 0.130 0.070 .00062 0.100 0.100 0.070 .00037 23 8/11/95 0.080 0.080 0.050 .00017 0.120 0.120 0.050 .00038 0.100 0.100 0.080 .00042 24 8/12/95 0.080 0.080 0.050 .00017 0.110 0.110 0.050 .00032 0.100 0.100 0.080 .00042 25 8/13/95 0.080 0.080 0.050 .00017 0.100 0.100 0.040 .00021 0.100 0.100 0.080 .00042 26 8/14/95 0.080 0.080 0.050 .00017 0.090 0.090 0.040 .00017 0.100 0.100 0.080 .00042 27 8/15/95 0.070 0.070 0.050 .00013 0.080 0.080 0.030 .00010 0.100 0.100 0.070 .00037 28 8/16/95 0.070 0.070 0.050 .00013 0.070 0.070 0.030 .00008 0.100 0.100 0.070 .00037 29 8/17/95 0.070 0.070 0.050 .00013 0.060 0.060 0.020 .00004 0.090 0.090 0.070 .00030 30 8/18/95 0.060 0.060 0.050 .00009 0.050 0.050 0.020 .00003 0.090 0.090 0.060 .00025 31 8/19/95 0.060 0.060 0.050 .00009 0.040 0.040 0.010 .00001 0.090 0.090 0.060 .00025 32 8/20/95 0.060 0.050 0.050 .00009 0.020 0.020 0.010 .00000 0.090 0.090 0.060 .00025 33 8/21/95 0.050 0.050 0.050 .00007 .00000 0.090 0.090 0.050 .00021 34 8/22/95 0.050 0.050 0.050 .00007 .00000 0.090 0.090 0.050 .00021 35 8/23/95 0.060 0.060 0.050 .00011 .00000 0.100 0.100 0.050 .00026 36 8/24/95 0.060 0.060 0.050 .00011 .00000 0.100 0.100 0.000 .00026 37 8/25/95 0.060 0.060 0.060 .00011 .00000 0.100 0.100 0.050 .00036 38 8/26/95 0.060 0.060 0.060 .00011 .00000 0.100 0.100 0.050 .00036 39 8/27/95 0.060 0.060 0.060 .00011 .00000 0.100 0.100 0.050 .00026 40 8/28/95 0.060 0.060 0.060 .00011 .00000 0.100 0.100 0.050 .00026 41 8/29/95 0.060 0.060 0.060 .00011 .00000 0.100 0.100 0.050 .00026 42 8/30/95 0.050 0.050 0.050 .00007 .00000 0.100 0.100 0.050 .00026 43 8/31/95 0.080 0.080 0.070 .00023 .00000 0.100 0.100 0.050 .00026 44 9/1/95 0.110 0.110 0.090 .00057 .00000 0.100 0.100 0.050 .00026 45 9/2/95 0.140 0.140 0.110 .00113 .00000 0.100 0.100 0.050 .00026 46 9/3/95 0.170 0.170 0.130 .00197 .00000 0.100 0.100 0.050 .00026 47 9/4/95 0.200 0.200 0.150 .00314 .00000 0.100 0.100 0.050 .00026 48 9/5/95 0.230 0.230 0.170 .00471 .00000 0.100 0.100 0.050 .00026 49 9/6/95 0.290 0.290 0.190 .00837 .00000 0.100 0.100 0.050 .00026 50 9/7/95 0.320 0.320 0.210 .01126 .0000 0.100 0.100 0.050 .00026 51 9/8/95 0.350 0.350 0.230 .01475 .0000 0.100 0.100 0.050 .00026 52 9/9/95 0.380 0.380 0.250 .01890 .0000 0.100 0.100 0.050 .00026 53 9/10/95 0.410 0.390 0.260 .02176 .0000 0.100 0.100 0.050 .00026 54 9/11/95 0.440 0.400 0.270 .02488 .0000 0.100 0.100 0.050 .00026 55 9/12/95 0.460 0.410 0.280 .02764 .0000 0.100 0.100 0.050 .00026 56 9/13/95 0.470 0.410 0.280 .02825 .0000 0.100 0.100 0.070 .00037 57 9/14/95 0.500 0.470 0.270 .03322 .0000 0.100 0.100 0.070 .00037 58 9/15/95 0.510 0.460 0.330 .04053 .0000 0.100 0.100 0.070 .00037 59 9/16/95 0.510 0.420 0.400 .04485 .0000 0.100 0.100 0.100 .00052 60 9/17/95 0.510 0.460 0.350 .04298 .0000 0.100 0.100 0.100 .00052 61 9/18/95 0.540 0.480 0.360 .04885 .0000 0.100 0.100 0.100 .00052 62 9/19/95 0.520 0.420 0.360 .04116 .0000 0.100 0.100 0.100 .00052 63 9/20/95 0.520 0.430 0.360 .04214 .0000 0.100 0.100 0.100 .00052 64 9/21/95 0.520 0.450 0.430 .05267 .0000 0.100 0.100 0.100 .00052 65 9/22/95 0.580 0.460 0.450 .06285 .0000 0.100 0.100 0.100 .00052 66 9/23/95 0.580 0.470 0.450 .06422 .0000 0.100 0.100 0.100 .00052 67 9/24/95 0.585 0.500 0.465 .07120 .0000 0.100 0.100 0.100 .00052 68 9/25/95 0.590 0.520 0.480 .07709 .0000 0.100 0.100 0.100 .00052 69 9/26/95 0.590 0.520 0.480 .07709 .0000 0.100 0.100 0.100 .00052 70 9/27/95 0.590 0.520 0.480 .07709 .0000 0.100 0.100 0.100 .00052 71 9/28/95 0.650 0.550 0.490 .09170 .0000 0.120 0.100 0.100 .00063 72 9/29/95 0.660 0.560 0.450 .08707 .0000 0.100 0.100 0.100 .00052 73 9/30/95 0.660 0.570 0.460 .09059 .0000 0.100 0.100 0.100 .00052 74 10/1/95 0.070 0.570 0.470 .09396 .0000 0.100 0.100 0.100 .00052 75 10/2/95 0.670 0.580 0.480 .09765 .0000 0.090 0.090 0.080 .00034 76 10/3/95 0.590 0.600 0.400 .07413 .0000 0.090 0.090 0.080 .00034 77 10/4/95 0.630 0.570 0.490 .09211 .0000 0.090 0.090 0.080 .00034 78 10/5/95 0.690 0.580 0.490 .10266 .0000 0.090 0.090 0.080 .00034 79 10/6/95 0.670 0.570 0.530 .10596 .0000 0.090 0.090 0.070 .00030 80 10/7/95 0.690 0.580 0.510 .10685 .0000 0.090 0.090 0.070 .00030 81 10/8/95 0.700 0.580 0.500 .10627 .0000 0.090 0.090 0.070 .00030 82 10/9/95 0.710 0.590 0.480 .10626 .0000 0.090 0.090 0.070 .00030 83 10/10/95 0.710 0.630 0.510 .11942 .0000 0.080 0.080 0.050 .00017 84 10/11/95 0.730 0.690 0.560 .14766 .0000 0.080 0.080 0.050 .00017 85 10/12/95 0.780 0.670 0.600 .16415 .0000 0.060 0.060 0.050 .00009 86 10/13/95 0.810 0.710 0.600 .18064 .0000 0.060 0.060 0.050 .00009 87 10/14/95 0.830 0.710 0.590 .18201 .0000 0.060 0.060 0.050 .00009 88 10/15/95 0.840 0.710 0.580 .18108 .0000 0.060 0.060 0.050 .00009 89 10/16/95 0.850 0.710 0.570 .18008 .0000 0.060 0.060 0.050 .00009 90 10/17/95 0.850 0.720 0.550 .17621 .0000 0.100 0.100 0.050 .00026 91 10/18/95 0.880 0.750 0.570 .19694 .0000 0.140 0.110 0.080 .00064 92 10/19/95 0.880 0.760 0.570 .19957 .0000 0.140 0.120 0.090 .00079 93 10/20/95 0.860 0.750 0.580 .19584 .0000 0.170 0.130 0.090 .00104 94 10/21/95 0.850 0.740 0.590 .19426 .0000 0.170 0.130 0.090 .00104 95 10/22/95 0.840 0.720 0.600 .18997 .0000 0.160 0.120 0.090 .00090 96 10/23/95 0.820 0.700 0.610 .18330 .0000 0.160 0.120 0.090 .00090 97 10/24/95 0.820 0.705 0.615 .18612 .0000 0.150 0.120 0.090 .00085 98 10/25/95 0.820 0.710 0.620 .18896 .0000 0.140 0.120 0.090 .00079 99 10/26/95 0.830 0.720 0.620 .19396 .0000 0.160 0.130 0.100 .00109 100 10/27/95 0.850 0.740 0.610 .20086 .0000 0.190 0.140 0.100 .00139 101 10/28/95 0.890 0.750 0.640 .22364 .00000 0.190 0.150 0.110 .00164 102 10/29/95 0.930 0.750 0.680 .24830 .00000 0.190 0.150 0.120 .00179 103 10/30/95 0.970 0.760 0.710 .27401 .00000 0.190 0.160 0.130 .00207 104 11/31/95 0.970 0.750 0.780 .29706 .00000 0.230 0.190 0.140 .00320 105 11/1/95 0.970 0.780 0.820 .32479 .00000 0.230 0.250 0.140 .00421 106 11/2/95 0.970 0.830 0.850 .35825 .00000 0.230 0.250 0.160 .00482 107 11/3/95 0.970 0.860 0.790 .34500 .00000 0.240 0.250 0.170 .00534 108 11/4/95 0.970 0.880 0.770 .34408 .00000 0.240 0.250 0.170 .00534 109 11/5/95 0.960 0.910 0.760 .34757 .00000 0.240 0.250 0.170 .00534 110 11/6/95 0.960 0.930 0.740 .34586 .00000 0.240 0.250 0.170 .00534 111 11/7/95 0.960 0.940 0.760 .35903 .00000 0.240 0.250 0.170 .00534 112 11/8/95 1.020 0.900 0.790 .37965 .00000 0.260 0.250 0.200 .00661 113 11/9/95 1.050 0.940 0.800 .41336 .00000 0.260 0.280 0.200 .00762 114 11/10/95 1.080 0.960 0.770 .41793 .00000 0.250 0.280 0.200 .00733 115 11/11/95 1.080 0.960 0.770 .41793 .00000 0.250 0.280 0.200 .00733 116 11/12/95 1.080 0.960 0.770 .41793 .00000 0.250 0.280 0.200 .00733 117 11/13/95 DIED 11/13/95 #VAL- DIED 11/13/95 #VAL- DIED 11/13/95 UE! UE! DAY DATE X Y Z DOB 11/26/94 A-488 LT ARM T-4 EVOL WEIGHT GRAMS HEMOTOCRIT 1 7/20/95 .00000 36.58 2 7/21/95 .00000 35.98 3 7/22/95 .00000 35.26 4 7/23/95 .00000 35.73 45 5 7/24/95 .00000 35.56 6 7/26/95 .00000 35.39 7 7/26/95 .00000 35.22 8 7/27/95 .00000 35.05 9 7/28/95 .00000 35.38 10 7/29/95 .00000 35.18 11 7/30/95 .00000 34.98 12 7/31/95 .00000 34.79 13 8/1/95 .00000 34.56 14 8/2/95 .00000 34.38 15 8/2/95 .00000 35.18 16 8/4/95 .00000 35.31 46 17 8/5/95 .00000 32.00 18 8/6/95 .00000 34.70 19 8/7/95 .00000 35.35 20 8/8/95 .00000 35.27 21 8/9/95 .00000 34.54 22 8/10/95 .00000 35.11 23 8/11/95 .00000 35.40 24 8/12/95 .00000 35.30 25 8/13/95 .00003 25.20 26 8/14/95 .00000 35.10 27 8/15/95 .00000 25.00 28 8/16/95 .00000 34.60 29 8/17/95 .00000 34.80 30 8/18/95 .00000 24.70 31 8/19/95 .00000 34.60 32 8/20/95 .00000 34.50 33 8/21/95 .00000 34.44 34 8/22/95 .00000 36.30 35 8/23/95 .00000 35.11 36 8/24/95 .00000 25.20 37 8/25/95 .00000 35.41 38 8/26/95 .00000 35.48 39 8/27/95 .00000 32.02 40 8/28/95 .00000 32.36 41 8/29/95 .00000 30.80 42 8/30/95 .00000 20.24 43 8/31/95 .00000 20.56 44 9/1/95 .00000 29.87 45 9/2/95 .00000 30.19 46 9/3/95 .00000 30.51 47 9/4/95 .00000 30.82 48 9/5/95 .00000 31.14 49 9/6/95 .00000 21.45 50 9/7/95 .00000 31.77 51 9/8/95 .00000 32.09 52 9/9/95 .00000 32.48 53 9/10/95 .00000 32.72 54 9/11/95 .00000 33.04 55 9/12/95 .00000 33.35 56 9/13/95 .00000 33.67 57 9/14/95 .00000 34.14 58 9/15/95 .00000 33.44 59 9/16/95 .00000 33.44 60 9/17/95 .00000 34.25 61 9/18/95 .00000 33.88 62 9/19/95 .00000 34.26 63 9/20/95 .00000 34.20 64 9/21/95 .00000 32.84 65 9/22/95 .00000 33.55 66 9/23/95 .00000 34.15 67 9/24/95 .00000 33.03 68 9/25/95 .00000 31.90 69 9/26/95 .00000 31.81 70 9/27/95 .00000 31.85 71 9/28/95 .00000 31.12 72 9/29/95 .00000 31.58 73 9/30/95 .00000 31.06 74 10/1/95 .00000 30.55 75 10/2/95 .00000 30.03 40 76 10/3/95 .00000 30.51 77 10/4/95 .00000 31.19 78 10/5/95 .00000 30.82 79 10/6/95 .00000 30.83 80 10/7/95 .00000 31.25 81 10/8/95 .00000 31.67 82 10/9/95 .00000 32.09 83 10/10/95 .00000 31.69 40 84 10/11/95 .00000 32.70 85 10/12/95 .00000 32.08 86 10/13/95 .00000 32.84 87 10/14/95 .00000 33.15 88 10/15/95 .00000 33.45 89 10/16/95 .00000 33.77 90 10/17/95 .00000 32.41 91 10/18/95 .00000 32.50 92 10/19/95 .00000 31.93 93 10/20/95 .00000 32.32 94 10/21/95 .00000 32.50 95 10/22/95 .00000 32.70 96 10/23/95 .00000 32.95 97 10/24/95 .00000 33.15 98 10/25/95 .00000 33.26 99 10/26/95 .00000 33.63 100 10/27/95 .00000 35.44 40 101 10/28/95 .00000 35.84 102 10/29/95 .00000 35.23 103 10/30/95 .00000 36.63 37 104 11/31/95 .00000 34.66 105 11/1/95 .00000 35.78 106 11/2/95 .00000 34.56 107 11/3/95 .00000 34.43 108 11/4/95 .00000 34.14 109 11/5/95 .00000 33.85 110 11/6/95 .00000 33.56 111 11/7/95 0.380 0.310 0.200 .01233 35.30 112 11/8/95 0.400 0.320 0.200 .01340 34.68 30 113 11/9/95 0.400 0.330 0.210 .01451 33.71 114 11/10/95 0.400 0.310 0.230 .01493 33.49 115 11/11/95 0.400 0.310 0.230 .01493 33.39 116 11/12/95 0.400 0.310 0.230 .01493 33.29 117 11/13/95 DIED 11/13/95 #VAL- 33 19 UE!

[0190] DAY DATE X Y Z EVOL X Y Z EVOL X Y Z EVOL X Y Z A-490 RT DOB 12/19/94 A-490 RT SIDE T-1 A-490 LT SIDE T-2 A-490 LT SIDE T-3 THIGH T-4  1 10/11/95 0.150 0.150 0.120 .00141 0.150 0.150 0.150 .00177 0.100 0.100 0.100 .00052  2 10/12/95 0.150 0.100 0.120 .00094 0.150 0.150 0.150 .00177 0.100 0.100 0.100 .00052  3 10/13/95 0.150 0.100 0.120 .00094 0.150 0.150 0.150 .00177 0.100 0.100 0.100 .00052  4 10/14/95 0.150 0.110 0.120 .00104 0.170 0.170 0.150 .00227 0.100 0.100 0.100 .00052  5 10/15/95 0.160 0.110 0.120 .00111 0.190 0.180 0.150 .00269 0.100 0.100 0.100 .00052  6 10/16/95 0.160 0.120 0.120 .00121 0.200 0.200 0.150 .00314 0.100 0.100 0.100 .00052  7 10/17/95 0.180 0.160 0.120 .00181 0.200 0.250 0.200 .00524 0.150 0.150 0.150 .00177  8 10/18/95 0.230 0.200 0.130 .00313 0.240 0.270 0.210 .00712 0.180 0.180 0.160 .00271  9 10/19/95 0.260 0.240 0.150 .00490 0.270 0.270 0.210 .00801 0.220 0.220 0.160 .00405 10 10/20/95 0.300 0.250 0.150 .00589 0.300 0.310 0.230 .01120 0.230 0.220 0.160 .00424 11 10/21/95 0.310 0.260 0.150 .00633 0.320 0.330 0.230 .01271 0.230 0.230 0.160 .00443 12 10/22/95 0.320 0.260 0.150 .00653 0.330 0.350 0.230 .01391 0.240 0.240 0.160 .00482 13 10/23/95 0.330 0.270 0.160 .00746 0.340 0.370 0.230 .01515 0.240 0.250 0.160 .00503 14 10/24/95 0.350 0.285 0.160 .00836 0.350 0.385 0.230 .01622 0.260 0.250 0.160 .00544 15 10/25/95 0.360 0.300 0.160 .00905 0.360 0.400 0.230 .01734 0.270 0.250 0.160 .00565 16 10/26/95 0.410 0.340 0.220 .01605 0.400 0.410 0.250 .02146 0.270 0.250 0.200 .00707 17 10/27/95 0.460 0.360 0.240 .02081 0.440 0.410 0.250 .02361 0.270 0.270 0.220 .00840 18 10/28/95 0.490 0.400 0.260 .02668 0.465 0.430 0.270 .02826 0.280 0.290 0.220 .00935 19 10/29/95 0.520 0.460 0.280 .03506 0.490 0.450 0.280 .03232 0.290 0.310 0.220 .01035 20 10/30/95 0.540 0.540 0.300 .04580 0.510 0.460 0.300 .03684 0.300 0.330 0.210 .01088 21 10/31/95 0.530 0.390 0.360 .03895 0.500 0.480 0.300 .03769 0.280 0.320 0.200 .00938 22 11/1/95  0.510 0.450 0.400 .04806 0.480 0.480 0.370 .04463 0.280 0.400 0.200 .01173 23 11/2/95  0.560 0.470 0.410 .05649 0.520 0.470 0.340 .04350 0.320 0.420 0.220 .01548 24 11/3/95  0.520 0.500 0.440 .05989 0.540 0.460 0.380 .04941 0.330 0.380 0.240 .01576 25 11/4/95  0.560 0.510 0.430 .06429 0.560 0.470 0.390 .05374 0.350 0.400 0.300 .02199 26 11/5/95  0.620 0.510 0.420 .06952 0.580 0.480 0.400 .05830 0.370 0.420 0.340 .02766 27 11/6/95  0.680 0.520 0.410 .07589 0.600 0.490 0.410 .06310 0.380 0.430 0.360 .03079 28 11/7/95  0.680 0.530 0.400 .07547 0.660 0.520 0.410 .07366 0.380 0.460 0.330 .03020 29 11/8/95  0.680 0.580 0.440 .09085 0.540 0.670 0.440 .08334 0.430 0.500 0.360 .04277 0.190 0.240 0.180 30 11/9/95  0.700 0.610 0.440 .09836 0.550 0.670 0.380 .07331 0.460 0.510 0.400 .04913 0.200 0.270 0.200 31 11/10/95 0.730 0.630 0.430 .10353 1.070 0.640 0.410 .14698 .00000 0.220 0.260 0.200 32 11/11/95 0.730 0.640 0.430 .10517 1.040 0.660 0.490 .17607 .00000 0.250 0.250 0.220 33 11/12/95 0.740 0.640 0.430 .10661 0.990 0.680 0.550 .19383 .00000 0.290 0.240 0.240 34 11/13/95 0.740 0.650 0.430 .10828 0.950 0.690 0.620 .21276 .00000 0.330 0.220 0.260 35 11/14/95 0.740 0.680 0.450 .11854 1.000 0.720 0.570 .21484 .00000 0.300 0.220 0.240 36 11/15/95 0.760 0.700 0.470 .13090 1.000 0.740 0.630 .24408 .00000 0.300 0.200 0.240 37 11/16/95 0.780 0.690 0.470 .13242 1.000 0.760 0.630 .25065 .00000 0.310 0.240 0.230 38 11/17/95 0.800 0.720 0.470 .14172 1.060 0.790 0.630 .27618 .00000 0.350 0.280 0.230 39 11/18/95 0.830 0.720 0.460 .14391 1.070 0.810 0.640 .29038 .00000 0.380 0.300 0.240 40 11/19/95 0.860 0.720 0.460 .14911 1.080 0.830 0.650 .30502 .00000 0.410 0.310 0.240 41 11/20/95 0.890 0.720 0.450 .15096 1.090 0.850 0.660 .32012 .00000 0.450 0.320 0.250 42 11/21/95 0.860 0.700 0.480 .15127 1.090 0.900 0.690 .35435 .00000 0.450 0.300 0.250 43 11/22/95 0.860 0.730 0.480 .15775 1.080 0.960 0.690 .37451 .00000 0.470 0.320 0.270 44 11/23/95 0.850 0.780 0.510 .17701 1.080 0.950 0.690 .37061 .00000 0.485 0.330 0.270 45 11/24/95 0.850 0.850 0.550 .20803 1.080 0.950 0.690 .37061 .00000 0.500 0.350 0.270 46 11/25/95 0.850 0.850 0.550 .20803 1.080 0.980 0.710 .39339 .00000 0.510 0.350 0.280 47 11/26/95 0.850 0.850 0.550 .20803 1.080 1.050 0.730 .43336 .00000 0.510 0.350 0.290 48 11/27/95 0.850 0.850 0.550 .20803 1.090 1.090 0.750 .46648 .00000 0.520 0.350 0.310 49 11/28/95 0.850 0.850 0.550 .20803 1.090 1.100 0.750 .47076 .00000 0.520 0.350 0.310 50 11/29/95 Died 11/29/95 #VAL- Died 11/29/95 #VAL- Died 11/29/95 #VAL- Died 11/29/95 UE! UE! UE! DOB 12/19/94 WEIGHT DAY DATE EVOL GRAMS  1 10/11/95 .00000 29.11 44  2 10/12/95 .00000 28.19  3 10/13/95 .00000 29.77  4 10/14/95 .00000 29.90  5 10/15/95 .00000 30.20  6 10/16/95 .00000 30.49  7 10/17/95 .00000 30.24  8 10/18/95 .00000 30.69  9 10/19/95 .00000 30.01 10 10/20/95 .00000 30.47 11 10/21/95 .00000 30.90 12 10/22/95 .00000 31.30 13 10/23/95 .00000 31.52 14 10/24/95 .00000 30.50 15 10/25/95 .00000 29.74 16 10/26/95 .00000 29.14 17 10/27/95 .00000 29.83 40 18 10/28/95 .00000 30.30 19 10/29/95 .00000 30.90 20 10/30/95 .00000 31.14 34 21 10/31/95 .00000 30.33 22 11/1/95  .00000 32.44 23 11/2/95  .00000 31.61 24 11/3/95  .00000 32.21 25 11/4/95  .00000 32.70 26 11/5/95  .00000 33.20 27 11/6/95  .00000 33.59 28 11/7/95  .00000 33.16 29 11/8/95  .00430 34.41 30 30 11/9/95  .00565 35.11 31 11/10/95 .00599 34.92 32 11/11/95 .00720 35.80 33 11/12/95 .00874 36.80 34 11/13/95 .00988 37.66 35 11/14/95 .00829 39.12 36 11/15/95 .00754 38.97 32 37 11/16/95 .00896 39.02 38 11/17/95 .01180 40.48 39 11/18/95 .01432 41.50 40 11/19/95 .01597 42.50 41 11/20/95 .01885 43.50 27 42 11/21/95 .01767 43.88 43 11/22/95 .02126 44.12 44 11/23/95 .02262 45.50 45 11/24/95 .02474 46.96 46 11/25/95 .02616 46.66 47 11/26/95 .02710 46.36 48 11/27/95 .02954 46.06 49 11/28/95 .02954 39.35 50 11/29/95 #VAL- 39.88 UE! T-1 AVERAGE GROWTH T-2 AVERAGE GROWTH T-3 AVERAGE GROWTH 0.560 0.491 0.340 0.078 0.644 0.560 0.413 0.137 0.254 0.276 0.202 0.011

[0191] DAY DATE X Y Z EVOL X Y Z EVOL X Y Z EVOL X Y Z EVOL A-492 RT ABDO- A-492 LT ABDO MEN T-1 MEN T-2 A-492 RT ARM T-3 A-492 LT ARM T-4 1 15-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 2 16-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 3 17-Sep 0.050 0.050 0.050 .00007 .00000 .00000 .00000 4 18-Sep 0.100 0.100 0.100 .00052 .00000 .00000 .00000 5 19-Sep 0.050 0.050 0.050 .00007 .00000 .00000 .00000 6 20-Sep 0.050 0.050 0.050 .00007 .00000 .00000 .00000 7 21-Sep 0.050 0.050 0.050 .00007 .00000 .00000 .00000 8 22-Sep 0.050 0.050 0.050 .00007 .00000 .00000 .00000 9 23-Sep 0.050 0.050 0.050 .00007 .00000 .00000 .00000 10 24-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 11 25-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 12 26-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 13 27-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 14 28-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 15 29-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 16 30-Sep 0.030 0.030 0.030 .00001 .00000 .00000 .00000 17  1-Oct .00000 .00000 .00000 .00000 18  2-Oct .00000 0.050 0.050 0.050 .00007 .00000 .00000 19  3-Oct .00000 0.050 0.050 0.050 .00007 .00000 .00000 20  4-Oct .00000 0.050 0.050 0.050 .00007 .00000 .00000 21  5-Oct .00000 0.030 0.030 0.030 .00001 .00000 .00000 22  6-Oct .00000 0.030 0.030 0.030 .00001 .00000 .00000 23  7-Oct .00000 0.040 0.040 0.040 .00003 .00000 .00000 24  8-Oct .00000 0.040 0.040 0.040 .00003 .00000 .00000 25  9-Oct .00000 0.050 0.050 0.050 .00007 .00000 .00000 26 10-Oct .00000 0.050 0.050 0.050 .00007 .00000 .00000 27 11-Oct .00000 0.050 0.050 0.050 .00007 0.100 0.100 0.100 .00052 .00000 28 12-Oct .00000 0.050 0.050 0.050 .00007 0.100 0.100 0.110 .00058 0.090 0.090 0.070 .00030 29 13-Oct .00000 0.050 0.050 0.050 .00007 0.100 0.100 0.100 .00052 0.090 0.090 0.060 .00025 30 14-Oct .00000 0.040 0.040 0.040 .00003 0.100 0.100 0.100 .00052 0.090 0.090 0.070 .00030 31 15-Oct .00000 0.040 0.040 0.040 .00003 0.100 0.100 0.100 .00052 0.090 0.090 0.080 .00034 32 16-Oct .00000 0.030 0.030 0.030 .00001 0.100 0.100 0.100 .00052 0.100 0.100 0.090 .00047 33 17-Oct .00000 0.030 0.030 0.030 .00001 0.150 0.150 0.150 .00177 0.120 0.120 0.110 .00083 34 18-Oct .00000 0.030 0.030 0.030 .00001 0.200 0.180 0.150 .00263 0.180 0.180 0.160 .00271 35 19-Oct .00000 0.030 0.030 0.030 .00001 0.240 0.200 0.150 .00377 0.210 0.200 0.160 .00352 36 20-Oct .00000 0.030 0.030 0.030 .00001 0.270 0.240 0.200 .00578 0.240 0.210 0.170 .00449 37 21-Oct .00000 0.030 0.030 0.030 .00001 0.270 0.240 0.200 .00678 0.260 0.240 0.170 .00555 38 22-Oct .00000 0.030 0.030 0.030 .00001 0.270 0.240 0.200 .00678 0.280 0.270 0.170 .00673 39 23-Oct .00000 0.030 0.030 0.030 .00001 0.270 0.240 0.200 .00678 0.290 0.290 0.170 .00748 40 24-Oct .00000 .00000 0.280 0.270 0.200 .00792 0.290 0.290 0.170 .00748 41 25-Oct .00000 .00000 0.300 0.300 0.200 .00942 0.290 0.300 0.180 .00820 42 26-Oct .00000 .00000 0.350 0.300 0.220 .01209 0.290 0.290 0.190 .00837 43 27-Oct .00000 .00000 0.340 0.300 0.240 .01282 0.290 0.280 0.200 .00850 44 28-Oct .00000 .00000 0.350 0.300 0.250 .01374 0.310 0.310 0.230 .01157 45 29-Oct .00000 .00000 0.350 0.300 0.250 .01374 0.330 0.340 0.250 .01468 46 30-Oct .00000 .00000 0.360 0.300 0.260 .01470 0.340 0.370 0.280 .01844 47 31-Oct .00000 .00000 0.340 0.320 0.270 .01538 0.320 0.360 0.270 .01719 48  1-Nov .00000 .00000 0.350 0.280 0.260 .01334 0.330 0.400 0.270 .01866 49  2-Nov .00000 .00000 0.360 0.300 0.280 .01583 0.350 0.400 0.270 .01979 50  3-Nov .00000 .00000 0.400 0.360 0.310 .02337 0.370 0.440 0.260 .02216 51  4-Nov .00000 .00000 0.420 0.340 0.290 .02168 0.355 0.450 0.270 .02258 52  5-Nov .00000 .00000 0.440 0.320 0.270 .01990 0.340 0.450 0.290 .02323 53  6-Nov .00000 .00000 0.450 0.300 0.250 .01767 0.330 0.460 0.300 .02384 54  7-Nov .00000 .00000 0.410 0.360 0.290 .02241 0.380 0.480 0.320 .03056 55  8-Nov .00000 .00000 0.460 0.350 0.300 .02529 0.420 0.530 0.360 .04195 56  9-Nov .00000 .00000 0.440 0.340 0.290 .02271 0.410 0.450 0.360 .03786 57 10-Nov .00000 .00000 0.470 0.350 0.320 .02756 0.490 0.500 0.380 .04277 58 11-Nov .00000 .00000 0.430 0.340 0.320 .02449 0.450 0.490 0.380 .04386 59 12-Nov .00000 .00000 0.390 0.320 0.320 .02091 0.460 0.490 0.390 .04602 60 13-Nov .00000 .00000 0.350 0.310 0.320 .01818 0.470 0.480 0.390 .04606 61 14-Nov .00000 .00000 0.390 0.310 0.300 .01899 0.480 0.500 0.360 .04523 62 15-Nov .00000 .00000 0.380 0.340 0.300 .02029 0.460 0.540 0.380 .04941 63 16-Nov .00000 .00000 0.380 0.340 0.290 .01961 0.470 0.510 0.370 .04643 64 17-Nov .00000 .00000 0.400 0.350 0.300 .02199 0.460 0.530 0.370 .04722 65 18-Nov .00000 .00000 0.400 0.380 0.320 0.2546 0.480 0.530 0.350 .04661 66 19-Nov .00000 .00000 0.410 0.410 0.340 .02992 0.490 0.530 0.330 .04486 67 20-Nov .00000 .00000 0.410 0.440 0.360 .03400 0.500 0.530 0.310 .04301 68 21-Nov .00000 .00000 0.430 0.430 0.330 .03194 0.500 0.430 0.320 .03602 69 22-Nov .00000 .00000 0.420 0.440 0.330 .03193 0.520 0.540 0.420 .06174 70 23-Nov .00000 .00000 0.440 0.470 0.370 .04006 0.520 0.520 0.410 .05804 71 24-Nov .00000 .00000 0.450 0.500 0.400 .04712 0.520 0.500 0.400 .05444 72 25-Nov .00000 .00000 0.470 0.500 0.390 .04798 0.530 0.510 0.390 .05519 73 26-Nov .00000 .00000 0.500 0.500 0.380 .04973 0.540 0.520 0.390 .05733 74 27-Nov .00000 .00000 0.520 0.500 0.370 .05036 0.550 0.530 0.380 .05799 75 28-Nov .00000 .00000 0.550 0.500 0.370 .05327 0.600 0.540 0.380 .06445 76 29-Nov .00000 .00000 0.570 0.490 0.370 .05410 0.640 0.610 0.380 .07766 77 30-Nov .00000 .00000 0.570 0.480 0.370 .05299 0.640 0.610 0.380 .07766 78  1-Dec .00000 .00000 0.560 0.460 0.390 .05259 0.500 0.660 0.370 .06392 79  2-Dec .00000 .00000 0.540 0.450 0.390 .04961 0.520 0.650 0.390 .06901 80  3-Dec .00000 .00000 0.520 0.450 0.390 .04777 0.530 0.560 0.410 .07280 81  4-Dec .00000 .00000 0.500 0.450 0.390 .04594 0.540 0.630 0.430 .07658 82  5-Dec .00000 .00000 0.660 0.470 0.390 .06333 0.570 0.650 0.430 .08340 83  6-Dec .00000 .00000 0.680 0.510 0.410 .07444 0.600 0.650 0.430 .08779 84  7-Dec .00000 .00000 0.590 0.510 0.430 .06773 0.630 0.690 0.430 .09785 85  8-Dec .00000 .00000 0.730 0.540 0.400 .08255 0.660 0.720 0.430 .10697 86  9-Dec .00000 .00000 0.740 0.540 0.400 .06368 0.690 0.730 0.430 .11339 87 10-Dec .00000 .00000 0.740 0.540 0.400 .06366 0.720 0.740 0.430 .11994 88 11-Dec .00000 .00000 0.750 0.540 0.400 .06481 0.750 0.750 0.440 .12957 89 12-Dec .00000 .00000 0.770 0.550 0.410 .09090 0.750 0.770 0.440 .13302 90 13-Dec .00000 .00000 0.790 0.560 0.420 .09727 0.750 0.790 0.440 .13648 91 14-Dec .00000 .00000 0.800 0.600 0.420 .10554 0.790 0.830 0.440 .15103 92 15-Dec .00000 .00000 0.810 0.630 0.400 .10686 0.800 0.810 0.480 .16283 93 16-Dec .00000 .00000 0.800 0.650 0.390 .10617 0.800 0.790 0.490 .16212 94 17-Dec .00000 .00000 0.800 0.670 0.370 .10382 0.800 0.760 0.510 .16233 95 18-Dec .00000 .00000 0.790 0.690 0.350 .09988 0.800 0.730 0.520 .15898 96 19-Dec .00000 .00000 0.810 0.650 0.350 .09647 0.780 0.720 0.510 .14994 97 20-Dec .00000 .00000 0.830 0.610 0.350 .09277 0.760 0.720 0.490 .14037 98 21-Dec .00000 .00000 0.780 0.610 0.370 .09216 0.780 0.730 0.500 .14904 99 22-Dec .00000 .00000 0.590 0.510 0.370 .05828 0.720 0.720 0.490 .13298 100 23-Dec .00000 .00000 0.590 0.520 0.370 .05943 0.720 0.710 0.490 .13113 101 24-Dec .00000 .00000 0.590 0.530 0.370 .06057 0.720 0.710 0.480 .12845 102 25-Dec .00000 .00000 0.590 0.540 0.360 .06004 0.730 0.700 0.480 .12840 103 26-Dec .00000 .00000 0.590 0.550 0.360 .06116 0.730 0.690 0.470 .12393 104 27-Dec .00000 .00000 0.580 0.550 0.360 .06012 0.730 0.690 0.470 .12393 105 28-Dec Died 12/29/95 #VAL- Died 12/29/95 #VAL- Died 12/29/95 #VAL- Died 12/29/95 VAL- UE! UE! UE! UE! WEIGHT DAY DATE GRAMS H'CRIT 1 15-Sep 29.62 2 16-Sep 29.29 3 17-Sep 30.45 4 18-Sep 30.47 5 19-Sep 30.09 6 20-Sep 29.85 7 21-Sep 28.88 8 22-Sep 29.35 9 23-Sep 29.62 10 24-Sep 29.11 11 25-Sep 28.61 12 26-Sep 29.58 13 27-Sep 27.84 14 28-Sep 26.53 15 29-Sep 28.91 16 30-Sep 28.85 17  1-Oct 28.60 18  2-Oct 28.42 45 19  3-Oct 28.54 20  4-Oct 29.13 21  5-Oct 28.81 22  6-Oct 29.33 23  7-Oct 29.38 24  8-Oct 29.42 25  9-Oct 29.45 26 10-Oct 28.60 42 27 11-Oct 29.43 28 12-Oct 28.68 29 13-Oct 29.43 30 14-Oct 29.70 31 15-Oct 29.90 32 15-Oct 30.12 33 17-Oct 29.26 34 18-Oct 29.50 35 19-Oct 28.78 36 20-Oct 29.22 37 21-Oct 29.23 38 22-Oct 29.25 39 23-Oct 29.27 40 24-Oct 29.26 41 25-Oct 29.26 42 26-Oct 28.63 43 27-Oct 29.84 43 44 28-Oct 29.92 45 29-Oct 29.99 46 30-Oct 30.05 43 47 31-Oct 28.61 48  1-Nov 29.49 49  2-Nov 28.96 50  3-Nov 28.68 51  4-Nov 29.00 52  5-Nov 29.10 53  6-Nov 29.24 54  7-Nov 29.55 55  8-Nov 31.49 40 56  9-Nov 30.03 57 10-Nov 29.88 58 11-Nov 29.76 59 12-Nov 29.66 60 13-Nov 29.46 61 14-Nov 31.17 62 15-Nov 30.31 46 63 16-Nov 32.11 64 17-Nov 31.42 65 18-Nov 31.60 66 19-Nov 31.80 67 20-Nov 32.05 41 68 21-Nov 31.57 69 22-Nov 32.02 70 23-Nov 32.20 71 24-Nov 32.46 72 25-Nov 32.55 73 26-Nov 32.65 74 27-Nov 32.78 75 28-Nov 32.41 76 29-Nov 33.63 35 77 30-Nov 32.70 78  1-Dec 33.26 79  2-Dec 33.66 80  3-Dec 34.10 81  4-Dec 34.51 82  5-Dec 34.29 83  6-Dec 34.76 38 84  7-Dec 34.82 85  8-Dec 34.87 86  9-Dec 35.47 87 10-Dec 36.00 88 11-Dec 36.55 89 12-Dec 36.65 90 13-Dec 36.73 17 91 14-Dec 37.34 92 15-Dec 37.92 93 16-Dec 35.50 94 17-Dec 34.00 95 18-Dec 32.59 96 19-Dec 31.90 97 20-Dec 31.30 9 98 21-Dec 32.45 99 22-Dec 32.70 100 23-Dec 33.50 101 24-Dec 34.30 102 25-Dec 35.10 103 26-Dec 35.90 104 27-Dec 36.84 T-1 AVERAGE GROWTH T-2 AVERAGE GROWTH T-3 AVERAGE GROWTH T-4 AVERAGE GROWTH 0.042 0.042 0.042 0.000 0.039 0.039 0.039 0.000 0.468 0.398 0.306 0.040 0.485 0.506 0.339 .06190

[0192] DAY DATE X Y Z EVOL X Y Z EVOL X Y Z EVOL A-500 RT WEIGHT H SIDE T-1 A-500 LT LEG T-2 A-500 RT BOT T-3 GRAMS CRIT  1 15-Sep 0.300 0.230 0.390 .0141 0.100 0.100 0.100 .0005 0.100 0.100 0.100 .0005 34.15  2 16-Sep 0.310 0.240 0.390 .0152 0.310 0.340 0.300 .0166 0.150 0.150 0.150 .0018 33.60  3 17-Sep 0.280 0.310 0.330 .0150 0.330 0.250 0.300 .0130 0.150 0.150 0.100 .0012 33.44  4 18-Sep 0.330 0.310 0.250 .0134 0.390 0.310 0.200 .0127 0.200 0.370 0.190 .0074 33.46  5 19-Sep 0.330 0.270 0.330 .0154 0.390 0.320 0.210 .0137 0.260 0.280 0.210 .0080 34.07  6 20-Sep 0.320 0.300 0.310 .0156 0.410 0.340 0.250 .0182 0.250 0.260 0.200 .0068 34.54  7 21-Sep 0.360 0.350 0.370 .0244 0.340 0.340 0.300 .0182 0.310 0.310 0.260 .0131 33.02  8 22-Sep 0.360 0.340 0.350 .0224 0.350 0.370 0.270 .0183 0.300 0.320 0.300 .0151 33.94  9 23-Sep 0.400 0.390 0.400 .0327 0.400 0.390 0.290 .0237 0.330 0.350 0.320 .0193 34.27 10 24-Sep 0.445 0.410 0.405 .0387 0.405 0.400 0.320 .0271 0.340 0.375 0.360 .0240 34.57 11 25-Sep 0.490 0.430 0.410 .0452 0.410 0.410 0.360 .0317 0.350 0.400 0.400 .0293 34.74 12 26-Sep 0.480 0.450 0.380 .0430 0.470 0.480 0.360 .0425 0.500 0.470 0.400 .0492 35.72 13 27-Sep 0.480 0.450 0.380 .0430 0.420 0.490 0.360 .0388 0.530 0.520 0.410 .0592 35.91 14 28-Sep 0.490 0.450 0.430 .0496 0.420 0.500 0.360 .0396 0.600 0.580 0.400 .0729 34.90 15 29-Sep 0.530 0.450 0.410 .0512 0.430 0.530 0.290 .0346 0.660 0.590 0.450 .0917 34.38 16 30-Sep 0.540 0.470 0.430 .0571 0.425 0.540 0.280 .0336 0.670 0.620 0.470 .1022 34.88 17  1-Oct 0.540 0.490 0.440 .0609 0.420 0.545 0.270 .0324 0.680 0.640 0.485 .1105 35.28 18  2-Oct 0.550 0.500 0.450 .0648 0.410 0.550 0.250 .0295 0.690 0.650 0.500 .1174 35.71 16 19  3-Oct 0.560 0.490 0.430 .0618 0.390 0.560 0.240 .0274 0.700 0.710 0.500 .1301 34.24 20  4-Oct 0.580 0.520 0.410 .0647 0.390 0.550 0.250 .0281 0.720 0.730 0.550 .1513 35.68 21  5-Oct 0.530 0.450 0.390 .0487 0.390 0.530 0.280 .0303 0.600 0.840 0.540 .1900 32.73 22  6-Oct 0.460 0.350 0.400 .0337 0.400 0.510 0.270 .0288 0.830 0.830 0.570 .2056 32.97 23  7-Oct 0.440 0.370 0.370 .0315 0.390 0.505 0.260 .0268 0.820 0.820 0.570 .2005 33.30 24  8-Oct 0.410 0.385 0.345 .0285 0.380 0.500 0.240 .0239 0.810 0.810 0.570 .1958 33.60 25  9-Oct 0.390 0.400 0.320 .0261 0.370 0.490 0.210 .0199 0.800 0.800 0.570 .1910 33.80 26 10-Oct 0.350 0.350 0.280 .0180 0.370 0.480 0.200 .0186 0.830 0.850 0.540 .1994 31.90 14 27 11-Oct DIED 10/11/95 #VAL- DIED 10/11/95 #VAL- DIED 10/11/95 #VAL- UE! UE! UE!

[0193] DAY DATE X Y Z EVOL X Y Z EVOL X Y Z EVOL GRAMS A-538 LT A-538 RT WEIGHT A-538 LT SIDE T-1 CHEEK T-2 ARMPIT T-3 GRAMS 1 19-Oct 0.200 0.300 0.160 .00503 .00000 .00000 29.67 2 20-Oct 0.200 0.340 0.190 .00676 .00000 .00000 30.24 3 21-Oct 0.220 0.340 0.190 .00744 .00000 .00000 30.10 4 22-Oct 0.240 0.330 0.190 .00788 .00000 .00000 30.00 5 23-Oct 0.260 0.330 0.190 .00853 .00000 .00000 29.93 6 24-Oct 0.250 0.350 0.200 .00916 .00000 .00000 30.12 7 25-Oct 0.250 0.380 0.220 .01094 .00000 .00000 30.20 8 26-Oct 0.260 0.300 0.240 .00980 .00000 .00000 29.30 9 27-Oct 0.260 0.340 0.240 .01111 .00000 .00000 29.69 46 10 28-Oct 0.280 0.340 0.240 .01196 .00000 .00000 29.80 11 29-Oct 0.290 0.340 0.240 .01239 .00000 .00000 29.87 12 30-Oct 0.300 0.340 0.240 .01262 .00000 .00000 29.93 41 13 31-Oct 0.300 0.320 0.240 .01206 .00000 .00000 29.51 14  1-Nov 0.310 0.300 0.230 .01120 .00000 .00000 30.26 15  2-Nov 0.350 0.290 0.250 .01328 .00000 .00000 30.34 16  3-Nov 0.340 0.210 0.250 .00934 .00000 .00000 30.39 17  4-Nov 0.360 0.240 0.240 .01086 .00000 .00000 30.20 18  5-Nov 0.380 0.270 0.240 .01289 .00000 .00000 30.10 19  6-Nov 0.390 0.300 0.220 .01347 .00000 .00000 30.02 20  7-Nov 0.390 0.330 0.260 .01752 .00000 .00000 29.94 21  8-Nov 0.400 0.340 0.290 .02065 .00000 .00000 30.67 45 22  9-Nov 0.400 0.300 0.280 .01759 .00000 .00000 28.55 23 10-Nov 0.410 0.340 0.280 .02043 .00000 .00000 28.86 24 11-Nov 0.430 0.360 0.300 .02431 .00000 .00000 29.20 25 12-Nov 0.470 0.370 0.320 .02913 .00000 .00000 29.60 26 13-Nov 0.500 0.380 0.330 .03262 .00000 .00000 29.88 27 14-Nov 0.520 0.400 0.320 .03484 .00000 .00000 29.16 28 15-Nov 0.540 0.420 0.320 .03799 .00000 .00000 29.41 42 29 16-Nov 0.570 0.410 0.320 .03915 .00000 .00000 29.33 30 17-Nov 0.600 0.410 0.320 .04121 .00000 .00000 30.45 31 18-Nov 0.620 0.420 0.330 .04499 .00000 .00000 30.41 32 19-Nov 0.640 0.440 0.330 .04865 .00000 .00000 30.38 33 20-Nov 0.660 0.450 0.340 .05286 .00000 .00000 30.33 46 34 21-Nov 0.650 0.490 0.340 .05669 .00000 .00000 30.07 35 22-Nov 0.670 0.490 0.350 .06015 0.220 0.240 0.200 .00553 .00000 29.97 36 23-Nov 0.685 0.510 0.360 .06584 0.220 0.240 0.200 .00553 .00000 30.50 37 24-Nov 0.700 0.530 0.360 .06992 0.220 0.240 0.200 .00678 .00000 31.23 38 25-Nov 0.700 0.520 0.370 .07050 0.240 0.240 0.200 .00603 .00000 31.30 39 26-Nov 0.700 0.510 0.380 .07102 0.270 0.240 0.200 .00678 .00000 31.40 40 27-Nov 0.700 0.500 0.390 .07146 0.290 0.250 0.200 .00759 .00000 31.56 41 28-Nov 0.700 0.500 0.390 .07146 0.300 0.270 0.220 .00933 .00000 31.66 42 29-Nov 0.700 0.550 0.390 .07860 0.340 0.300 0.220 .01175 .00000 32.41 41 43 30-Nov 0.780 0.530 0.390 .08440 0.360 0.320 0.220 .01327 .00000 32.39 44  1-Dec 0.760 0.520 0.400 .08275 0.350 0.440 0.260 .02096 .00000 32.12 45  2-Dec 0.780 0.540 0.400 .08820 0.350 0.450 0.260 .02144 .00000 32.80 46  3-Dec 0.800 0.560 0.400 .09381 0.360 0.460 0.260 .02254 .00000 33.20 47  4-Dec 0.820 0.570 0.400 .09767 0.370 0.470 0.260 .02367 .00000 33.54 48  5-Dec 0.860 0.560 0.450 .11345 0.400 0.470 0.260 .02559 .00000 33.48 49  6-Dec 0.860 0.560 0.450 .11345 0.420 0.490 0.300 .03232 0.200 0.200 0.200 .00419 34.32 30 50  7-Dec 0.870 0.580 0.450 .11887 0.450 0.500 0.300 .03534 0.210 0.200 0.180 .00396 34.86 51  8-Dec 0.870 0.590 0.450 .12092 0.440 0.500 0.330 .03801 0.210 0.200 0.180 .00396 34.83 52  9-Dec 0.890 0.600 0.470 .13139 0.500 0.540 0.330 .04664 0.210 0.210 0.190 .00439 35.50 53 10-Dec 0.900 0.600 0.480 .13569 0.550 0.570 0.330 .05416 0.220 0.220 0.200 .00507 36.20 54 11-Dec 0.910 0.610 0.490 .14239 0.590 0.590 0.330 .06014 0.230 0.230 0.200 .00554 36.97 55 12-Dec 0.930 0.620 0.470 .14187 0.590 0.590 0.330 .06014 0.240 0.240 0.200 .00603 37.20 56 13-Dec 0.950 0.630 0.460 .14412 0.590 0.590 0.330 .06014 0.250 0.250 0.210 .00687 37.43 29 57 14-Dec 0.940 0.630 0.460 .14261 0.660 0.640 0.330 .07297 0.290 0.280 0.210 .00893 37.65 58 15-Dec 0.930 0.620 0.460 .13885 0.660 0.640 0.340 .07518 0.290 0.270 0.210 .00851 38.15 59 16-Dec 0.910 0.610 0.450 .13077 0.700 0.680 0.350 .08722 0.290 0.270 0.210 .00861 37.60 60 17-Dec 0.880 0.610 0.440 .12365 0.750 0.710 0.350 .09757 0.290 0.270 0.210 .00861 36.90 61 18-Dec 0.850 0.600 0.430 .11480 0.800 0.740 0.360 .11157 0.290 0.270 0.210 .00861 36.24 62 19-Dec 0.870 0.590 0.430 .11555 0.780 0.740 0.360 .10878 0.310 0.300 0.220 .01071 37.20 63 20-Dec 0.890 0.590 0.430 .11820 0.750 0.740 0.360 .10460 0.330 0.330 0.220 .01254 38.26 21 64 21-Dec 0.930 0.620 0.470 .14187 0.760 0.780 0.360 .11172 0.330 0.330 0.230 .01311 38.65 65 22-Dec 0.980 0.790 0.570 .23102 0.780 0.780 0.390 .12421 0.330 0.330 0.230 .01311 39.82 66 23-Dec 1.000 0.820 0.570 .24468 0.800 0.800 0.390 .13067 0.350 0.330 0.240 .01451 40.80 67 24-Dec 1.050 0.840 0.560 .25857 0.810 0.810 0.390 .13395 0.380 0.340 0.250 .01691 41.90 68 25-Dec 1.100 0.860 0.560 .27733 0.820 0.820 0.440 .15488 0.410 0.340 0.260 .01897 42.80 69 26-Dec 1.130 0.890 0.550 .28957 0.830 0.830 0.440 .15868 0.440 0.350 0.260 .02096 43.80 70 27-Dec 1.160 0.920 0.540 .30169 0.830 0.850 0.440 .16250 0.460 0.350 0.270 .02276 44.75 27 71 28-Dec 1.220 1.000 0.550 .35127 0.850 0.870 0.450 .17421 0.460 0.380 0.285 .02068 44.00 72 29-Dec 1.280 1.040 0.560 .39025 0.870 0.890 0.460 .18646 0.460 0.400 0.300 .02890 43.38 73 30-Dec 1.290 1.060 0.570 .40803 0.880 0.900 0.480 .19901 0.470 0.400 0.310 .03051 43.70 74 31-Dec 1.290 1.070 0.580 .41910 0.880 0.920 0.490 .20767 0.470 0.400 0.310 .03051 44.00 75  1-Jan 1.300 1.090 0.590 .43766 0.890 0.940 0.500 .21898 0.480 0.400 0.320 .03216 44.31 76  2-Jan 1.300 1.100 0.610 .45665 0.890 0.960 0.500 .22364 0.480 0.400 0.320 .03216 45.18 77  3-Jan 1.300 1.100 0.610 .45665 0.900 0.960 0.510 .23068 0.480 0.400 0.320 .03216 43.22 24 78  4-Jan 1.300 1.100 0.610 .45665 0.920 0.970 0.540 .25227 0.460 0.400 0.320 .03082 44.61 79  5-Jan 1.300 1.110 0.610 .46080 0.920 0.970 0.560 .26162 0.480 0.400 0.300 .03015 44.33 80  6-Jan 1.280 1.150 0.620 .47777 0.930 0.980 0.570 .27196 0.480 0.400 0.300 .03015 44.70 81  7-Jan 1.260 1.200 0.640 .50658 0.940 0.990 0.580 .28256 0.490 0.400 0.300 .03078 45.00 82  8-Jan 1.240 1.250 0.660 .53554 0.950 0.990 0.580 .28556 0.330 0.400 0.300 .01885 45.50 83  9-Jan 1.210 1.280 0.670 .54323 0.960 1.000 0.590 .29561 0.300 0.400 0.300 .01885 45.80 84 10-Jan 1.190 1.300 0.680 .55070 0.970 1.000 0.590 .29960 0.310 0.400 0.300 .01947 46.20 23 85 11-Jan 1.180 1.310 0.690 .55837 0.970 1.010 0.600 .30712 0.310 0.400 0.300 .01947 46.58 86 12-Jan 1.200 1.300 0.690 .56350 0.970 1.010 0.630 .32311 0.330 0.400 0.300 .02073 47.33 87 13-Jan .00000 .00000 .00000 88 14-Jan .00000 .00000 .00000 89 15-Jan Died 1/15/96 #VAL- Died 1/15/96 #VAL- Died 1/15/96 #VAL- UE! UE! UE! T-1 AVERAGE GROWTH T-2 AVERAGE GROWTH T-3 AVERAGE GROWTH 0.740 0.593 0.399 0.142 0.638 0.658 0.369 0.112 0.357 0.328 0.254 0.018

[0194] DOB 3/25/95 A-540 NECK T-1 A-540 T-2 WEIGHT HE DAY DATE X Y Z EVOL X Y Z EVOL GRAMS CT  1 15-Nov 0.280 0.260 0.210 .00800 .00000 29.97 40  2 16-Nov 0.290 0.280 0.230 .00978 .00000 30.89  3 17-Nov 0.290 0.290 0.230 .01013 .00000 30.11  4 18-Nov 0.290 0.290 0.230 .01013 .00000 30.11  5 19-Nov 0.300 0.290 0.240 .01093 .00000 30.10  6 20-Nov 0.300 0.290 0.240 .01093 .00000 30.10 41  7 21-Nov 0.320 0.290 0.240 .01186 .00000 29.92  8 22-Nov 0.360 0.340 0.220 .01410 .00000 30.17  9 23-Nov 0.380 0.360 0.220 .01576 .00000 30.50 10 24-Nov 0.400 0.370 0.220 .01705 .00000 30.94 11 25-Nov 0.420 0.390 0.240 .02058 .00000 31.30 12 26-Nov 0.440 0.410 0.260 .02455 .00000 31.50 13 27-Nov 0.450 0.430 0.280 .02836 .00000 31.64 14 28-Nov 0.450 0.430 0.260 .02634 .00000 29.92 15 29-Nov 0.470 0.440 0.260 .02815 .00000 30.29 29 16 20-Nov 0.530 0.450 0.260 .03246 .00000 29.83 17  1-Dec 0.490 0.440 0.300 .03386 .00000 29.61 18  2-Dec 0.510 0.450 0.320 .03845 .00000 29.90 19  3-Dec 0.530 0.460 0.330 .04212 .00000 30.38 20  4-Dec 0.550 0.470 0.340 .04601 .00000 30.78 21  5-Dec 0.550 0.460 0.340 .04503 .00000 29.63 22  6-Dec 0.550 0.500 0.340 .04895 .00000 30.60 28 23  7-Dec 0.570 0.530 0.370 .05852 .00000 30.06 24  8-Dec 0.580 0.550 0.400 0.6680 .00000 29.97 25  9-Dec 0.600 0.570 0.400 .07161 .00000 29.94 26 10-Dec 0.600 0.590 0.400 .07413 .00000 29.83 27 11-Dec 0.610 0.610 0.400 .07792 .00000 29.91 28 12-Dec 0.650 0.620 0.410 .08650 .00000 30.50 29 13-Dec 0.680 0.630 0.410 .09195 .00000 31.26 26 30 14-Dec 0.700 0.650 0.430 .10242 .00000 30.47 31 15-Dec 0.720 0.680 0.450 .11534 .00000 36.56 32 16-Dec 0.740 0.680 0.440 .11591 .00000 35.20 33 17-Dec 0.760 0.690 0.440 .12079 .00000 34.00 34 18-Dec 0.800 0.690 0.430 .12426 .00000 33.38 35 19-Dec 0.820 0.710 0.440 .13410 .00000 33.00 36 20-Dec 0.840 0.720 0.450 .14248 .00000 32.69 19 37 21-Dec 0.750 0.890 0.450 .15725 .00000 34.22 38 22-Dec 0.810 0.790 0.650 .21774 .00000 35.08 39 23-Dec 0.850 0.820 0.670 .24447 .00000 35.60 40 24-Dec 0.890 0.850 0.690 .27326 .00000 36.20 41 25-Dec 0.930 0.880 0.710 .30419 .00000 36.80 42 26-Dec 1.000 0.910 0.730 .34776 .00000 37.90 43 27-Dec 1.060 0.950 0.740 .39010 .00000 38.77 26 44 28-Dec 1.070 0.980 0.720 .39524 .00000 38.00 45 29-Dec 1.090 0.910 0.700 .36348 .00000 37.47 46 30-Dec 1.090 0.910 0.700 .36348 .00000 36.00 47 31-Dec 1.100 0.910 0.700 .36682 .00000 34.50 48  1-Jan 1.100 0.910 0.700 .36682 .00000 33.08 49  2-Jan Died 01/02/96 #VAL- .00000 50 T-1 AVERAGE GROWTH 0.637 0.584 0.413 0.119

[0195] DOB 03/25/95 A-542 NECK T-1 A-542 LT ARM T-2 WEIGHT HE DAY DATE X Y Z EVOL X Y Z EVOL GRAMS CT  1 27-Nov 0.350 0.400 0.360 .02638 .00000 28.99  2 28-Nov 0.370 0.410 0.370 .02938 .00000 29.65  3 29-Nov 0.400 0.450 0.400 .03769 .00000 29.47 40  4 30-Nov 0.440 0.480 0.430 .04754 .00000 29.26  5  1-Dec 0.470 0.500 0.400 .04921 .00000 29.68  6  2-Dec 0.480 0.520 0.410 .05357 .00000 29.90  7  3-Dec 0.490 0.540 0.430 .05956 .00000 30.20  8  4-Dec 0.500 0.550 0.440 .06334 .00000 30.36  9  5-Dec 0.510 0.550 0.440 .06461 .00000 30.19 10  6-Dec 0.510 0.550 0.450 .06608 .00000 30.73 40 11  7-Dec 0.550 0.580 0.470 .07849 .00000 31.18 12  8-Dec 0.550 0.620 0.480 .08569 .00000 31.69 13  9-Dec 0.570 0.690 0.490 .10089 .00000 32.20 14 10-Dec 0.590 0.760 0.510 .11972 .00000 32.90 15 11-Dec 0.610 0.830 0.520 .13782 .00000 33.33 16 12-Dec 0.650 0.845 0.530 .15239 .00000 33.90 17 13-Dec 0.690 0.860 0.520 .16154 0.300 0.240 0.150 .00565 34.59 34 18 14-Dec 0.710 0.920 0.540 .18465 0.300 0.240 0.150 .00565 35.65 19 15-Dec 0.720 0.890 0.550 .18450 0.280 0.270 0.150 .00594 35.39 20 16-Dec 0.800 0.940 0.580 .22833 0.280 0.270 0.210 .00831 36.00 21 17-Dec 0.890 0.980 0.600 .27396 0.270 0.270 0.260 .00992 36.80 22 18-Dec 0.960 1.010 0.620 .31470 0.270 0.270 0.300 .01145 37.56 23 19-Dec 0.920 1.050 0.650 .32871 0.250 0.260 0.250 .00851 38.75 24 20-Dec 0.890 1.090 0.690 .35041 0.190 0.250 0.200 .00497 40.02 33 25 21-Dec 0.910 1.120 0.690 .36815 0.240 0.260 0.200 .00653 40.04 26 22-Dec 0.960 1.010 0.610 .30953 0.230 0.380 0.200 .00915 39.57 27 23-Dec 0.960 1.010 0.600 .30455 0.230 0.380 0.200 .00915 38.80 28 24-Dec 0.960 1.010 0.600 .30455 0.220 0.380 0.200 .00875 38.20 29 25-Dec 0.950 1.010 0.590 .29636 0.220 0.380 0.200 .00875 37.60 30 26-Dec 0.950 1.010 0.590 .29636 0.210 0.380 0.200 .00836 37.00 31 27-Dec 0.940 1.010 0.590 .29324 0.200 0.380 0.190 .00756 36.36 32 32 28-Dec 0.950 1.015 0.530 .26754 0.225 0.380 0.210 .00940 37.40 33 29-Dec 0.960 1.020 0.450 .23068 0.250 0.390 0.220 .01123 38.52 34 30-Dec 0.970 1.040 0.470 .24821 0.270 0.400 0.220 .01244 39.10 35 31-Dec 0.980 1.070 0.480 .26349 0.290 0.410 0.230 .01432 39.70 36  1-Jan 0.980 1.090 0.490 .27401 0.320 0.410 0.230 .01580 40.20 37  2-Jan 0.980 1.110 0.520 .29612 0.320 0.430 0.240 .01729 41.92 38  3-Jan 0.960 1.140 0.510 .29219 0.340 0.470 0.240 .02008 43.00 30 39  4-Jan 0.930 1.260 0.520 .31899 0.360 0.470 0.260 .02303 46.30 40  5-Jan 0.960 1.110 0.520 .29008 0.400 0.470 0.270 .02657 37.13 41  6-Jan 0.960 1.110 0.540 .30123 0.440 0.490 0.310 .03499 37.40 42  7-Jan 0.960 1.110 0.560 .31239 0.480 0.510 0.350 .04485 37.80 43  8-Jan 0.960 1.100 0.580 .32063 0.530 0.530 0.390 .05735 38.10 44  9-Jan 0.960 1.100 0.600 .33169 0.570 0.540 0.410 .06606 38.40 45 10-Jan 0.960 1.100 0.620 .34275 0.610 0.550 0.430 .07552 38.60 30 46 11-Jan 0.960 1.100 0.620 .34275 0.660 0.550 0.440 .08361 38.80 47 12-Jan 0.950 1.000 0.630 .31331 0.650 0.570 0.430 .08340 38.84 48 13-Jan 0.990 1.000 0.630 .32651 0.710 0.590 0.440 .09549 39.80 49 14-Jan 1.020 1.010 0.620 .33437 0.780 0.600 0.450 .11025 40.70 50 15-Jan 1.050 1.010 0.620 .34421 0.840 0.610 0.450 .12071 41.65 51 16-Jan 1.040 0.970 0.620 .32743 0.830 0.640 0.460 .12792 42.40 52 17-Jan 1.040 0.990 0.580 .31262 0.870 0.640 0.470 .13700 40.85 30 53 18-Jan Died 1/18/96 #VAL- Died 1/18/96 #VAL- UE! UE! 54 19-Jan T-1 AVERAGE GROWTH T-2 AVERAGE GROWTH 55 20-Jan 0.803 0.897 0.536 0.226 0.401 0.424 0.284 0.034

[0196] A-592 LT DOB 6/27/95 A-592 LT LEG T-1 ARMPIT T-2 A-592 RT ARM T-3 WEIGHT HE DAY DATE X Y Z EVOL X Y Z EVOL X Y Z EVOL GRAMS CT  1 16-Jan 0.480 0.380 0.170 .0162 .0000 .0000 32.86  2 17-Jan 0.530 0.380 0.200 .0211 0.210 0.200 0.110 .0024 .0000 31.03 41  3 18-Jan 0.550 0.430 0.220 .0272 0.200 0.200 0.100 .0021 .0000 31.64  4 19-Jan 0.560 0.440 0.220 .0284 0.200 0.200 0.100 .0021 .0000 30.94  5 20-Jan 0.620 0.480 0.250 .0389 0.200 0.190 0.100 .0020 .0000 30.60  6 21-Jan 0.680 0.530 0.280 .0528 0.200 0.190 0.100 .0020 .0000 31.20  7 22-Jan 0.740 0.570 0.300 .0662 0.200 0.180 0.100 .0019 .0000 31.98  8 23-Jan 0.800 0.610 0.300 .0766 0.190 0.170 0.100 .0017 .0000 32.51  9 24-Jan 0.810 0.670 0.300 .0852 0.200 0.180 0.110 .0021 .0000 34.80 35 10 25-Jan 0.830 0.680 0.310 .0916 0.200 0.210 0.110 .0024 .0000 36.02 11 26-Jan 0.920 0.750 0.340 .1228 0.200 0.210 0.110 .0024 .0000 35.83 12 27-Jan 0.950 0.750 0.350 .1305 0.200 0.210 0.110 .0024 .0000 36.80 13 28-Jan 0.890 0.750 0.350 .1360 0.190 0.200 0.110 .0022 .0000 37.80 14 29-Jan 1.030 0.750 0.460 .1860 0.190 0.200 0.110 .0022 0.260 0.270 .0080 .0029 38.59 15 30-Jan 1.110 0.810 0.490 .2306 0.210 0.200 0.110 .0024 0.260 0.280 0.090 .0034 42.38 16 31-Jan 1.150 0.850 0.500 .2559 0.240 0.200 0.110 .0028 0.260 0.290 0.120 .0047 42.30 25 17  1-Feb 1.170 0.840 0.540 .2778 0.230 0.200 0.110 .0026 0.280 0.300 0.120 .0053 42.44 18  2-Feb 1.220 1.000 0.590 .3768 0.250 0.260 0.110 .0037 0.270 0.290 0.120 .0049 44.98 19  3-Feb 1.340 1.070 0.610 .4579 0.250 0.260 0.110 .0037 0.290 0.290 0.120 .0053 45.97 20  4-Feb 1.360 1.100 0.650 .5091 0.230 0.250 0.110 .0033 0.310 0.300 0.140 .0068 46.80 21  5-Feb 1.480 1.140 0.690 .6094 0.220 0.240 0.120 .0033 0.330 0.300 0.150 .0078 48.63 22  6-Feb 1.430 1.150 0.710 .6112 0.220 0.240 0.120 .0033 0.340 0.310 0.150 .0083 50.98 23  7-Feb 1.500 1.200 0.760 .7161 0.220 0.240 0.120 .0033 0.360 0.340 0.160 .0103 51.25 20 24  8-Feb 1.520 1.240 0.760 .7499 0.200 0.210 0.120 .0026 0.360 0.340 0.160 .0103 53.65 25  9-Feb 1.600 1.250 0.760 .7957 0.210 0.210 0.130 .0030 0.360 0.340 0.160 .0103 54.20 26 10-Feb 1.640 1.270 0.760 .8287 0.220 0.210 0.130 .0031 0.360 0.350 0.160 .0106 54.80 27 11-Feb 1.680 1.290 0.760 .8622 0.230 0.220 0.130 .0034 0.360 0.360 0.170 .0115 56.40 28 12-Feb 1.750 1.300 0.760 .9051 0.240 0.220 0.140 .0039 0.360 0.370 0.170 .0119 56.06 29 13-Feb 1.700 1.340 0.760 .9053 0.220 0.220 0.120 .0030 0.360 0.360 0.170 .0115 50.11 30 14-Feb 1.680 1.350 0.690 .8192 0.220 0.260 0.140 .0042 0.380 0.360 0.210 .0150 50.57 31 15-Feb Died 2/15/96 #VAL- Died 2/15/96 #VAL- Died 2/15/96 #VAL- UE! UE! UE!

[0197] DOB 6/27/95 A-594 RT SIDE T-1 A-594 T-2 WEIGHT HE DAY DATE X Y Z EVOL X Y Z EVOL GRAMS CT  1 12-Jan 0.160 0.200 0.090 .00151 .00000 41.92  2 13-Jan 0.200 0.210 0.090 .00198 .00000 41.40  3 14-Jan 0.240 0.220 0.100 .00276 .00000 40.80  4 15-Jan 0.270 0.230 0.100 .00325 .00000 40.20  5 16-Jan 0.270 0.220 0.090 .00283 .00000 39.95  6 17-Jan 0.280 0.230 0.100 .00337 .00000 39.73  7 18-Jan 0.260 0.240 0.110 .00359 .00000 39.49  8 19-Jan 0.280 0.280 0.140 .00575 .00000 39.60  9 20-Jan 0.300 0.280 0.150 .00660 .00000 39.10 10 21-Jan 0.340 0.290 0.150 .00774 .00000 38.50 11 22-Jan 0.360 0.290 0.160 .00874 .00000 38.06 12 23-Jan 0.390 0.300 0.230 .01409 .00000 39.57 13 24-Jan 0.450 0.340 0.240 .01922 .00000 39.28 43 14 25-Jan 0.400 0.360 0.260 .02254 .00000 39.32 15 26-Jan 0.500 0.390 0.290 .02960 .00000 39.09 16 27-Jan 0.520 0.420 0.290 .03316 .00000 38.80 17 28-Jan 0.530 0.440 0.290 .03540 .00000 38.30 18 29-Jan 0.550 0.470 0.290 .03924 .00000 37.97 19 30-Jan 0.560 0.490 0.290 .04166 .00000 38.79 20 31-Jan 0.590 0.530 0.340 .05566 .00000 38.82 38 21  1-Feb 0.640 0.570 0.340 .08493 .00000 39.08 22  2-Feb 0.670 0.610 0.360 .07702 .00000 39.85 23  3-Feb 0.700 0.640 0.370 .06678 .00000 39.65 24  4-Feb 0.740 0.670 0.360 .09344 .00000 39.90 25  5-Feb 0.790 0.700 0.360 .10422 .00000 40.20 26  6-Feb 0.860 0.790 0.300 .10670 .00000 39.53 27  7-Feb 0.920 0.940 0.340 .15393 .00000 38.66 32 28  8-Feb 1.020 1.010 0.290 .15640 .00000 37.37 29  9-Feb 1.030 1.030 0.290 .15106 .00000 36.40 30 10-Feb 1.050 1.050 0.280 .16160 .00000 35.00 31 11-Feb 1.060 1.070 0.280 .16625 .00000 33.50 32 12-Feb 1.070 1.080 0.280 .16939 .00000 31.95 33 13-Feb 1.110 1.060 0.310 .19094 .00000 30.87 34 14-Feb 1.110 1.100 0.270 .17258 .00000 33.88 20 35 15-Feb 1.170 1.090 0.270 .18026 .00000 34.31 36 16-Feb Died 2/16/96 #VAL- .00000 UE!

APPENDIX C TREATED MOUSE DATA (EXTERNAL MODULATOR EMBODIMENT)

[0198] Index (Pages numbered on back) Appendix Subject Pages C1 OUJ-738 116

[0199] T-1 Lt Underarm Vol WEIGHT HEMATO- TREATMENT PARAMETERS DAY DATE Ln Wd Ht T-1 Gr CRIT-% DEVICE FREQ MHz POWER TIME FREQ MHz  1  5-Mar 0.110 0.110 0.110 .00070 37.95 8662A 43351855.0 43353800.0  2  6-Mar 0.110 0.110 0.110 .00070 36.83 8662A 43351855.0 43353800.0  3  7-Mar 0.100 0.110 0.100 .00058 36.00 8662A 43351855.0 43353800.0  4  8-Mar 0.110 0.100 0.100 .00058 36.02 46 8662A 43351855.0 43353800.0  5  9-Mar 0.110 0.100 0.100 .00058 36.25 NO TREATMENT NO TREATMENT  6 10-Mar 0.100 0.100 0.100 .00052 36.56 8662A 43351855.0 43353800.0  7 11-Mar 0.110 0.100 0.090 .00052 35.32 8662A 43351855.0 43353800.0  8 12-Mar 0.110 0.110 0.080 .00051 34.88 8662A 43346000.0 43353800.0  9 13-Mar 0.120 0.120 0.070 .00053 35.11 8662A 43351855.0 43346000.0 10 14-Mar 0.130 0.120 0.070 .00057 34.91 8662A 43351855.0 43353800.0 11 15-Mar 0.140 0.130 0.060 .00057 34.84 44 8662A 43351855.0 43353800.0 12 16-Mar 0.145 0.130 0.065 .00064 35.20 NO TREATMENT NO TREATMENT 13 17-Mar 0.150 0.130 0.070 .00071 35.58 8662A 43351855.0 43353800.0 14 18-Mar 0.150 0.130 0.070 .00071 35.25 8662A 43351855.0 43353800.0 15 19-Mar 0.150 0.120 0.070 .00066 33.66 8662A 43351855.0 43353800.0 16 20-Mar 0.160 0.120 0.070 .00070 33.81 8662A 43351855.0 43353800.0 17 21-Mar 0.160 0.120 0.070 .00070 32.67 8662A 43351855.0 43353800.0 18 22-Mar 0.160 0.130 0.070 .00076 32.83 43 8662A 43351855.0 43353800.0 19 23-Mar 0.160 0.130 0.070 .00076 33.23 NO TREATMENT NO TREATMENT 20 24-Mar 0.170 0.130 0.080 .00093 33.63 8662A 43351855.0 43353800.0 21 25-Mar 0.180 0.130 0.080 .00098 33.01 8662A 43351855.0 43353800.0 22 26-Mar 0.190 0.130 0.070 .00091 32.69 8662A 43351855.0 43353800.0 23 27-Mar 0.190 0.130 0.080 .00103 31.25 8662A 43351855.0 43353800.0 24 28-Mar 0.190 0.130 0.080 .00103 31.63 8662A 43351855.0 43353800.0 25 29-Mar 0.190 0.130 0.080 .00103 31.11 44 8662A 43351855.0 43353800.0 26 30-Mar 0.190 0.130 0.080 .00103 31.36 NO TREATMENT NO TREATMENT 27 31-Mar 0.200 0.130 0.070 .00095 31.64 8662A 43351855.0 43353800.0 28  1-Apr 0.210 0.130 0.070 .00100 31.83 8662A 43351855.0 43353800.0 29  2-Apr 0.210 0.130 0.070 .00100 31.11 8662A 43351855.0 43353800.0 30  3-Apr 0.210 0.140 0.070 .00108 31.80 8662A 43351855.0 43353800.0 31  4-Apr 0.220 0.140 0.080 .00129 30.98 8662A 43351855.0 43353800.0 32  5-Apr .00000 NO TREATMENT NO TREATMENT 33  6-Apr .00000 TREATMENT PARAMETERS DAY DATE POWER TIME DEVICE  1  5-Mar 0.0 dBm 1, 1 SW & HP  2  6-Mar 0.0 dBm 1, 1 SW & HP  3  7-Mar 0.0 dBm 1, 1 SW & HP  4  8-Mar 0.0 dBm 1, 1 SW & HP  5  9-Mar  6 10-Mar 0.0 dBm 1, 1 SW & NP  7 11-Mar 0.0 dBm 1, 1 SW & NP  8 12-Mar 0.0 dBm 1, 1 SW & NP  9 13-Mar 0.0 dBm 1, 1 SW & NP 10 14-Mar 0.0 dBm 1, 1 SW & NP 11 15-Mar 0.0 dBm 1, 1 SW & HP 12 16-Mar 13 17-Mar 0.0 dBm 1, 1 SW & HP 14 18-Mar 0.0 dBm 1, 1 SW & HP 15 19-Mar 0.0 dBm 1, 1 SW & HP 16 20-Mar 0.0 dBm 1, 1 SW & HP 17 21-Mar 0.0 dBm 1, 1 SW & HP 18 22-Mar 0.0 dBm 1, 1 SW & HP 19 23-Mar 20 24-Mar −40 dBm  1, 1 SW & HP 21 25-Mar −50 dBm  1, 1 SW & HP 22 26-Mar 0.0 dBm 1, 1 SW & HP 23 27-Mar 0.0 dBm 1, 1 SW & HP 24 28-Mar 0.0 dBm 1, 1 SW & HP 25 29-Mar 0.0 dBm 1, 1 SW & HP 26 30-Mar 27 31-Mar 0.0 dBm 1, 1 SW & HP 28  1-Apr 0.0 dBm 1, 1 SW & HP 29  2-Apr 0.0 dBm 1, 1 SW & HP 30  3-Apr 0.0 dBm 1, 1 SW & HP 31  4-Apr 0.0 dBm 1, 1 SW & HP 32  5-Apr 33  6-Apr 

We claim:
 1. Therapeutic apparatus, comprising means for generating an approximately 60 Hz., 50% duty cycle square wave signal pulsed at a second 50% duty cycle at approximately 1.167 Hz., a quartz crystal with a resonant frequency in the radio frequency range, serially driven by said signal, a wire loop, the input of which is serially driven by the output of said quartz crystal, and the other end of which is grounded with respect to said square wave generating means.
 2. The apparatus of claim 1, wherein the frequency of the crystal is selected from the group of frequencies consisting of: 43,322,480 Hz., 43,322,492 Hz., 43,322,485 Hz., 43,346,000 Hz., 43,346,090 Hz., 43,346,000 Hz., 43,346,050 Hz., 43,353,800 Hz., 43,353,800 Hz., 43,353,850 Hz., 43,353,800 Hz., 43,296,000 Hz., 43,351,830 Hz., 43,351,850 Hz., 43,351,855 Hz., 43,351,870 Hz., 43,352,000 Hz., and 43,245,000 Hz., all ±20 Hz.
 3. The apparatus of claim 1, wherein the means for generating said approximately 60 Hz., 50% duty cycle square wave signal pulsed at a second 50% duty cycle at approximately 1.167 Hz. comprises means for generating a first square wave of approximately 60 Hz., at a duty cycle of approximately 50%, means for generating a second square wave of approximately 1.167 Hz., at a duty cycle of approximately 50%, and means for ANDing said first square wave and said second square wave.
 4. The apparatus of claim 3, wherein between said ANDing means and said crystal there is inserted a series LC filtering means comprising an inductor and a variable capacitor.
 5. The apparatus of claim 4, wherein said wire loop is made from approximately five turns spaced approximately 3.175 mm. apart of a wire approximately 60 cm. long.
 6. The apparatus of claim 5, wherein said wire loop is mounted on the housing of the apparatus.
 7. The apparatus of claim 6, wherein the power supply for the apparatus comprises a battery housed within the apparatus so as to render the apparatus self-contained.
 8. The apparatus of claim 6, wherein the power supply for the apparatus comprises an external, power line driven transformer.
 9. Therapeutic apparatus, comprising, a stable frequency generator means having a modulation input, a range of radio frequency outputs, the ability to provide output at a steady power of 1 mw or less, and the ability to provide radio frequency output tunable to at least one half a part per million, a modulator, connected to said modulation input, providing an approximately 60 Hz., 50% duty cycle square wave signal pulsed at a second 50% duty cycle at approximately 1.167 Hz., and a wire loop, one end of which is connected to the output of said frequency generator means, and the other end of which is grounded with respect to said frequency generator means.
 10. The apparatus of claim 9, wherein said radio frequency output is selected from the group of frequencies consisting of: 43,322,480 Hz., 43,322,492 Hz., 43,322,485 Hz., 43,346,000 Hz., 43,346,090 Hz., 43,346,000 Hz., 43,346,050 Hz., 43,353,800 Hz., 43,353,800 Hz., 43,353,850 Hz., 43,353,800 Hz., 43,296,000 Hz., 43,351,830 Hz., 43,351,850 Hz., 43,351,855 Hz., 43,351,870 Hz., 43,352,000 Hz., and 43,245,000 Hz., all ±20 Hz.
 11. The apparatus of claim 9, wherein said modulator comprises means for generating a first square wave of approximately 60 Hz. at a duty cycle of approximately 50%, means for generating a second square wave of approximately 1.167 Hz. at a duty cycle of approximately 50%, and means for ANDing said first square wave and said second square wave.
 12. Therapeutic apparatus, comprising, a stable frequency generator means having a range of radio frequency outputs, the ability to provide output at a steady power of 1 mw or less, and the ability to provide radio frequency output tunable to at least one half a part per million, a modulator, connected in series to the radio frequency output of said modulation input, providing an approximately 60 Hz., 50% duty cycle square wave signal pulsed at a second 50% duty cycle at approximately 1.167 Hz., and a wire loop, one end of which is connected to the output of said frequency generator means, and the other end of which is grounded with respect to said frequency generator means.
 13. The apparatus of claim 12, wherein said radio frequency output is selected from the group of frequencies consisting of: 43,322,480 Hz., 43,322,492 Hz., 43,322,485 Hz., 43,346,000 Hz., 43,346,090 Hz., 43,346,000 Hz., 43,346,050 Hz., 43,353,800 Hz., 43,353,800 Hz., 43,353,850 Hz., 43,353,800 Hz., 43,296,000 Hz., 43,351,830 Hz., 43,351,850 Hz., 43,351,855 Hz., 43,351,870 Hz., 43,352,000 Hz., and 43,245,000 Hz., all ±20 Hz.
 14. The apparatus of claim 12, wherein said modulator comprises means for generating a first square wave of approximately 60 Hz. at a duty cycle of approximately 50%, means for generating a second square wave of approximately 1.167 Hz. at a duty cycle of approximately 50%, means for ANDing said first square wave and said second square wave, and means responsive to said ANDed first and second square wave for switching a series radio frequency signal.
 15. The apparatus of claim 12 wherein, said wire loop is connected to the output of said frequency generator means by a Hewlett-Packard 10501A or equivalent shielded coaxial cable.
 16. A method for treating cancer and other illnesses in a human or animal subject, comprising, generating a radio frequency signal tuned to a treatment frequency that has been specified to a precision of at least one half of a part per million; modulating said radio frequency with an approximately 60 Hz. square wave with an approximately 50% duty cycle which has been gated by an approximately 1.167 Hz. square wave with an approximately 50% duty cycle applying said modulated radio frequency signal at a power of 1 mw or less to one end of a wire loop and grounding the other end of said loop, placing said wire loop to which said modulated radio frequency signal has been applied on the surface of the subject's body for a period of at least one hour.
 17. The method of claim 16, wherein said radio frequency is selected from the group of frequencies consisting of: 43,322,480 Hz., 43,322,492 Hz., 43,322,485 Hz., 43,346,000 Hz., 43,346,090 Hz., 43,346,000 Hz., 43,346,050 Hz., 43,353,800 Hz., 43,353,800 Hz., 43,353,850 Hz., 43,353,800 Hz., 43,296,000 Hz., 43,351,830 30 Hz., 43,351,850 Hz., 43,351,855 Hz., 43,351,870 Hz., 43,352,000 Hz., and 43,245,000 Hz., all ±20 Hz.
 18. The method of claim 16, wherein said wire loop is made from approximately five turns spaced approximately 3.175 cm. apart of a wire approximately 60 cm. long
 19. A low power, precisely tuned, stable RF generator comprising, means for generating a sequence of audio frequency square waves, and a quartz crystal tuned to an RF frequency, connected in series to said square wave generating means. 